Association of four CpG-SNPs in the vascular-related genes with coronary heart disease |
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| Institution: | 1. Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio;2. Department of Biostatistics, University of Washington, Seattle, Washington;3. Cardiology Section, San Francisco Veterans Affairs Health Care System, and Department of Medicine, University of California San Francisco, San Francisco, California;4. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington;5. Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles, California;6. Department of Medicine, University of Maryland, Baltimore, Maryland;7. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington;8. Kaiser Permanente Washington Research Institute, Seattle, Washington;9. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California;1. Department of Medicine, Stavanger University Hospital, Stavanger, Norway;2. Department of Natural Sciences, University of Agder, Kristiansand, Norway;3. Department of Medicine, Haukeland University Hospital, Bergen, Norway;4. Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norway |
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| Abstract: | Vascular-related gene polymorphism can affect the susceptibility of coronary heart disease. In current study, we aimed to evaluate the contribution of four vascular-related gene CpG-SNPs to coronary heart disease (CHD). A total of 784 angiography-proven CHD patients and 746 non-CHD controls were included in the current association study. The four CpG-SNPs (including VEGFA rs1005230, ACE rs4316, CST3 rs3827143 and AGTR1 rs275653) were genotyped using the Sequenom MassARRAY platform. All genotype distribution of four SNPs met HWE. Among the four CpG-SNPs, none was found to be associated with CHD on both genotype and allele levels. Further subgroup tests by age or gender were unable to observe any significant associations of them with CHD. Our case-control study showed that none of four CpG-SNPs in the vascular-related genes was associated with the risk of CHD in Han Chinese, although we could not exclude other genetic variants of these vascular-related genes with contribution to CHD. |
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| Keywords: | Coronary heart disease CpG-SNPs Polymorphism |
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