Simultaneous determination of 31 elements in foodstuffs by ICP-MS after closed-vessel microwave digestion: Method validation based on the accuracy profile |
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| Institution: | 1. Department of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran;2. Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Chemistry, Faculty of Sciences, Islamic Azad University, Kerman Branch, Kerman, Iran;4. Department of Medical Biotechnology, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran;5. Medical Biotechnology Research Center, Guilan University of Medical Sciences, Rasht, Iran;1. UT2A, Hélioparc Pau-Pyrénées, 2 Avenue du président Angot, 64053 Pau, France;2. Université de Paris-Est, Anses, Laboratoire de Sécurité des Aliments, 94700 Maisons-Alfort, France;3. Anses, Direction de l’Evaluation des Risques, 94700 Maisons-Alfort, France;4. AP/HP, Département de Pharmacologie Clinique et Unité de Recherche Clinique (URCEST), Hôpital Saint Antoine, 75012 Paris, France;5. Réseau Médic-Al, Paris, France;6. Université de la Sorbonne Paris 6, UPMC, Département de Pharmacologie, Paris, France;1. Université Paris-Est, Anses, Laboratory for Food Safety, F-94701 Maisons-Alfort, France;2. The French Directorate General for food, Ministry of Agriculture, Agro-Food and Forestry, F-75732 Paris, France |
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| Abstract: | This article describes an optimisation and validation process for the simultaneous determination of 31 elements – lithium, boron, sodium, magnesium, aluminium, potassium, calcium, titanium, vanadium, chromium, iron, manganese, cobalt, nickel, copper, zinc, gallium, germanium, arsenic, selenium, strontium, molybdenum, silver, cadmium, tin, antimony, tellurium, barium, mercury, lead and uranium – in food samples by inductively coupled plasma-mass spectrometry (ICP-MS) after closed-vessel microwave digestion. In order to improve the limits of quantification of certain elements for risk assessment in the context of the first French Infant Total Diet Study (iTDS), the analytical conditions of the multi-elemental method were optimised. The validation was conducted using the evaluation of several performance criteria such as linearity, specificity, precision under repeatability conditions, intermediate precision reproducibility and limits of quantification (LOQ), with the use of the accuracy profile. Furthermore, the method was supervised by several external quality controls (EQC). Results indicate that this method could be used in the laboratory for the routine determination of these 31 essential and non-essential elements in foodstuffs with acceptable analytical performance. A more sensitive method will be necessary for Hg and Pb to decrease at the lowest the percentage of left-censored data for this iTDS. |
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| Keywords: | Method validation ICP-MS Microwave digestion Quality controls Foodstuffs French Infant Total Diet Study Food composition Food analysis |
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