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Intolerance of uncertainty as a mediator of reductions in worry in a cognitive behavioral treatment program for generalized anxiety disorder
Affiliation:1. University of California, San Diego, Department of Psychiatry, USA;2. Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, USA;3. SDSU/UCSD Joint Doctoral Program in Clinical Psychology, USA;4. Laureate Institute for Brain Research, Tulsa, OK, USA;5. VA San Diego Health Care System Center of Excellence for Stress and Mental Health, San Diego, California, USA;6. University of California, San Diego, Department of Family Medicine and Public Health, USA;1. Department of Psychology, University of Regina, Saskatchewan, Canada;2. School of Psychology and Speech Pathology, Curtin University, Perth, Australia;3. Department of Psychology, University of Houston, Texas, USA;4. MD Anderson Cancer Center, University of Texas, Texas, USA;5. Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands;6. Clinical Research Unit for Anxiety and Depression, University of New South Wales at St Vincent''s Hospital, Sydney, Australia;7. Department of Psychology, University of Wollongong, Wollongong, Australia;1. Department of Psychology, Temple University, 1701 North 13th Street, 6th Floor, Philadelphia, PA 19122, United States;2. Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, United States;1. Department of Psychology, Government Degree College, Baramulla, 193101, India;2. Department of Psychology, Jamia Millia Islamia, New Delhi, 110025, India;1. School of Psychology and Speech Pathology, Curtin University, Perth, Australia;2. Centre of Clinical Interventions, Perth, Australia;3. Health Psychology and Behavioural Medicine Research Group, Curtin University, Perth, Australia;4. School of Psychology, University of Sydney, Sydney, Australia;1. Centre for Clinical Interventions, Perth, Australia;2. School of Psychology and Speech Pathology, Curtin University, Perth, Australia
Abstract:Growing evidence suggests that intolerance of uncertainty (IU) is a cognitive vulnerability that is a central feature across diverse anxiety disorders, including generalized anxiety disorder (GAD). Although cognitive behavioral therapy (CBT) has been shown to reduce IU, it remains to be established whether or not reductions in IU mediate reductions in worry. This study examined the process of change in IU and worry in a sample of 28 individuals with GAD who completed CBT. Changes in IU and worry, assessed bi-weekly during treatment, were analyzed using multilevel mediation models. Results revealed that change in IU mediated change in worry (ab = −0.20; 95% CI [−.35, −.09]), but change in worry did not mediate change in IU (ab = −0.16; 95% CI [−.06, .12]). Findings indicated that reductions in IU accounted for 59% of the reductions in worry observed over the course of treatment, suggesting that changes in IU are not simply concomitants of changes in worry. Findings support the idea that IU is a critical construct underlying GAD.
Keywords:Intolerance of uncertainty  Anxiety  Worry  GAD  Treatment
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