Detection of Autoantibodies and Increased Concentrations of Interleukins in Plasma from Patients with Tourette's Syndrome |
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Authors: | Cheng Yu-Hang Zheng Yi He Fan Yang Jian-Hong Li Wen-Biao Wang Min-Ling Cui De-Yan Chen Ying |
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Affiliation: | Clinical Examination and Experimental Center, Beijing An Ding Hospital, Capital Medical University, Beijing, 100088, People's Republic of China. |
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Abstract: | The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n?=?40) and healthy control individuals (n?=?40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group (P?0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group (P?0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group (P?0.05). These findings suggest that immune activity is altered in patients with TS. |
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