| 香豆素-7-磺酰脲类化合物的合成及降血糖活性研究 |
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| 引用本文： | 祁刚,屠树滋.香豆素-7-磺酰脲类化合物的合成及降血糖活性研究[J].中国现代应用药学,2010,27(3):199-202. |
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| 作者姓名： | 祁刚 屠树滋 |
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| 作者单位： | 盐城工学院化生学院;中国药科大学药物化学教研室; |
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| 基金项目： | 江苏省留学奖学金; 教育厅资助项目(08KJD350005) |
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| 摘 要： | 目的寻找新型降糖活性的化合物。方法运用拼合原理将磺酰脲类降糖活性化合物的药效团磺酰脲基与有降糖活性的香豆素拼合,设计合成了香豆素磺酰脲类化合物。结果设计并合成了6个新的化合物,该类化合物未见文献报道,结构均经IR、1H-NMR、MS鉴定。结论初步药理实验表明MSU-3在2h和4h对正常小鼠都有明显的降血糖作用(P<0.01,与0.5%CMC-Na组比较)。
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| 关 键 词： | 香豆素-7-磺酰脲 合成 降血糖活性 |
Synthesis of Coumarin-7-sulfonylurea and Study on its Hypoglycemic Activity |
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| QI Gang,TU Shuzi.Synthesis of Coumarin-7-sulfonylurea and Study on its Hypoglycemic Activity[J].The Chinese Journal of Modern Applied Pharmacy,2010,27(3):199-202. |
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| Authors: | QI Gang TU Shuzi |
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| Institution: | QI Gang,TU Shuzi(.Department of Chemistry,Biology,Yancheng Institute of Technology,Yancheng,Chin,.Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing,China |
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| Abstract: | OBJECTIVE To search some new compounds which have hypoglycemic activities. METHODS Novel coumarin-7-sulfonylurea compounds were designed and synthesized by combining the active moieties of hypoglycemic drugs. Their hypoglycemic activities were evaluated in mice. RESULTS These 6 targeted compounds were synthesized and characterized by FT-IR, 1H-NMR and MS spectra. CONCLUSION The preliminary results showed that MSU-3 exhibited evident hypoglycemic effect (P<0.01, CMC-Na as negative control) at the dose of 50 mg·kg-1, suggesting the promising potential for further investigation. |
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| Keywords: | coumarin-7-sulfonylureas synthesis hypoglycemic activity |
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