壳聚糖屏障膜机械性能与降解性能的研究

目的 :研究壳聚糖膜的机械性能和降解性能。方法 :制备用于引导组织再生的壳聚糖膜 ,以聚四氟乙烯膜 (e -PTFE)为对照 ,用 1195型Instron电子拉力机测定膜的抗张强度、屈服强度和伸长率 ,并测量其体内、外降解过程中重量丧失率和分子量变化。结果 :充分湿润后 ,壳聚糖膜的机械强度显著降低 ,伸长率显著增高。但即使在湿润状态下 ,壳聚糖膜的机械强度仍显著高于e -PTFE膜 ,伸长率显著低于e -PTFE膜 (P <0 .0 1)。在溶菌酶存在情况下 ,壳聚糖膜具有较快的降解速度 :3 0d时重量丧失约 3 0 % ,40d时重量丧失约 46% ,60d后 ,膜基本破碎溶解。结论 :从材料的机械性能和降解性能上看 ,壳聚糖膜基本符合用于引导组织再生的要求。

Study of mechanical strength and degradation performance of chitosan barrier membrane

Objective:The purpose of the present study was to study mechanical strength and degradation performance of chitosan barrier membrane.Method: Chitosan membrane was prepared for guided tissue regeneration. The tensile strength, tensile yield strength and tensile strain rate were measured with type 1195 electronic tensile apparatus, with expanded polytetrafluoroethylene membrane (e-PTFE) as control. The weight lose rate and molecular weight variety were measured also. Result: The tensile strength of fully sopped chitosan membrane reduced remarkably, while it's tensile strain rate increased remarkably. However, the tensile strength of fully sopped chitosan membrane was much more than the tensile strength of e-PTFE(p<0.01). Chitosan membrane were degraded more rapidly with lysozyme. The weight lose rate was 30% at 30th day and at 40th day. At 60th day, chitosan membrane dissolved fully. Conclusion: From the point of view of mechanical strength and degradation performance, Chitosan membrane meet the requirements of guided tissue regeneration.