扶正解毒方对原发性非小细胞肺癌患者生存质量的影响

目的:观察扶正解毒方对原发性非小细胞肺癌患者生存质量的影响。方法:将60例晚期非小细胞肺癌患者随机分为中药组、化疗组及中药加化疗组。中药组治以扶正解毒方,化疗组以NP或GP方案治疗,中药加化疗组予以扶正解毒方和化疗,治疗时间均为8周。以卡氏评分和QLQ-C30量表为工具评价扶正解毒方对肺癌患者生存质量的影响。结果:中药组、中药加化疗组卡氏评分增加稳定率分别为90%、85%,化疗组为75%,中药组疗效优于化疗组(P<0.05);中药组治疗后QLQ-C30量表中躯体功能、角色功能、情绪功能、疲倦、疼痛、呼吸困难、食欲丧失、大便异常情况等维度计分较治疗前下降,总健康状况计分升高(P<0.05,P<0.01);中药加化疗组治疗后情绪功能计分明显下降(P<0.01),疲倦、恶心呕吐、经济计分明显上升(P<0.01),且情绪功能计分下降与化疗组相比差异显著(P<0.01);化疗组治疗后躯体功能、角色功能等维度,以及疲倦、恶心呕吐等计分均较治疗前上升(P<0.05或P<0.01)。结论:扶正解毒方能够明显提高非小细胞肺癌患者生存质量。

Effects of "Fuzheng Jiedu Decoction" on Quality of Life of Patients with Non-small Cell Lung Cancer

Objective: To assess the effect of "Fuzheng Jiedu Decoction" on quality of life(QOL) of patients with non-small cell lung cancer. Methods: Sixty patients with non-small cell lung cancer were randomly divided into three groups: TCM group, TCM combined with chemotherapy group, and chemotherapy group. Patients in TCM group were treated with "Fuzheng Jiedu Decoction" , patients in chemotherapy group were treated with chemotherapy, and those in TCM combined with chemotherapy group were treated with "Fuzheng Jiedu Decoction" plus chemotherapy. Karnovsky performance status(KPS) and EORTC QLQ-C30 were used to assess the quality of life of these patients. Results: The rate of improvement and stability in KPS was 90% for patients in TCM group, as compared with 75% for those in chemotherapy group, P<0.01. In TCM group, the scores of the functions of body, role, emotion, and the symptoms of fatigue, pain, dyspnea, loss of appetite and disorder of stool all descended after treatment, P<0.05, and the score of total health significantly increased, P<0.01. In TCM combined with chemotherapy group, the score of the function of emotion significantly declined, but the scores of fatigue and vomiting as well as the cost of the treatment significantly increased. In chemotherapy group and TCM combined with chemotherapy group, the scores of nausea and vomiting increased after treatment, P<0.01.In chemotherapy group, the scores of the functions of body, role, the symptoms of fatigue and vomiting significantly increased after treatment. Conclusion: "Fuzheng Jiedu Decoction" can improve the quality of life of non-small cell lung cancer patient.