Cathepsin K expression is diminished in infants with bronchopulmonary dysplasia |
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| Authors: | Knaapi Jonni Lukkarinen Heikki Kiviranta Riku Steiner Aida Lassus Patrick Andersson Sture Kääpä Pekka |
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| Affiliation: | Research Centre of Applied and Preventive Cardiovascular Medicine,;Department of Paediatrics, University of Turku, Turku, Finland;, Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland;, Department of Medicine, University of Turku, Turku, Finland;, and Department of Paediatrics, University of Helsinki, Helsinki, Finland |
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| Abstract: | The expression of a potent collagenolytic enzyme, cathepsin K, was measured in repeated tracheal aspirate samples from premature infants with and without a chronic lung disorder, bronchopulmonary dysplasia (BPD). At 9–13 d, but not before, cathepsin K expression was significantly lower in the lungs of premature infants developing BPD. Conclusion: Insufficient pulmonary cathepsin K in BPD may predispose premature lungs to pulmonary fibrosis. |
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| Keywords: | Bronchopulmonary dysplasia cathepsin K chronic lung disease |
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