中西医结合三联疗法经验性治疗慢性功能性便秘临床观察

目的:观察中西医结合三联疗法经验性治疗慢性功能性便秘的临床疗效和安全性。方法:通过随机平行对照设计,将符合纳入/排除标准的180例患者按1:1:1比例随机分为3组,A组60例予中西医结合经验性三联疗法治疗,B组60例给予福松治疗,C组60例给予福松联合麻仁软胶囊治疗。疗程4周,观察治疗前、疗程结束时、随访1周、1个月、3个月等固定时间便秘症状情况,并予评分量化。采用尼莫地平评分法判断疗效,并进行比较。结果:疗程结束时,3组的有效率分别为A组91.38%、B组86.67%、C组94.73%,A组分别与B组、C组相比,疗效无显著差异(P>0.05);随访1周,3组的有效率分别为A组87.93%、B组73.33%、C组77.19%,A组分别与B组、C组相比,疗效无显著差异(P>0.05);随访1个月,3组的有效率分别为A组82.76%、B组51.67%、C组57.89%,A组分别与B组、C组相比,疗效有显著差异(P<0.05);随访3个月,3组的有效率分别为A组65.52%、B组23.33%、C组33.33%,A组分别与B组、C组相比,疗效有显著差异(P<0.05)。3组均未出现严重不良事件。结论:中西医结合三联疗法经验性治疗慢性功能性便秘具有中远期疗效且安全。

Clinical Observation of Empirical Triple Treatment for Chronic Functional Constipation with Combination of TCM and Western Medicine

Objective:To observe the clinical efficacy and safety of empirical triple treatment for Chronic functional constipation with combination of TCM and Western medicine.Methods:180 patients were randomly assigined to three groups according to 1:1:1 ratio.Administered the 60 cases of treatment group A with empirical treatment which were combined with TCM and Western medicine,administered the 60 cases of treatment group B with Forlax,administered the 60 cases of treatment group C with Mziren capsule and Forlax.The duration of treatment in groups was 1 month.Observed and scored symptoms of constipation before and at the end of the treatment,following up the cases one week later,four weeks later,and three months later.Evaluated and compared the effect by Nimodipine score.Results:At the end of the treatment,the effective rate were 91.38%(group A),86.67%(group B),94.73%(group C) respectively.Compared with group B and group C,group A has no significant difference(P>0.05).followed-up 1 week after treatment,the effective rate were 87.93%(group A),73.33%(group B),77.19%(group C) respectively.Compared with group B and group C,group A has no significant difference(P>0.05).Followed-up 1 month after treatment,the effective rate were 82.76%(group A),51.67%(group B),57.89%(group C) respectively.Compared with group B and group C,group A has no significant difference(P<0.05).Followed-up 3 months after treatment,the effective rate were 65.52%(group A),23.33%(group B),33.33%(group C)respectively.Compared with group B and group C,group A has no significant difference(P<0.05).The adverse reaction did not happen among three groups.Conclusion:Empirical triple treatment for chronic functional constipation with combination of TCM and Western medicine has the long-term efficacy and safety.