Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population |
| |
| Authors: | Mamtani Manju Mummidi Srinivas Ramsuran Veron Pham Minh-Hieu Maldonado Robert Begum Kazi Valera Maria Soledad Sanchez Racquel Castiblanco John Kulkarni Hemant Ndung'u Thumbi He Weijing Anaya Juan Manuel Ahuja Sunil K |
| |
| Affiliation: | The Veterans Administration Center for AIDS and HIV-1 infection and Center for Personalized Medicine, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center, San Antonio, USA. |
| |
| Abstract: | We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
