| 重组人生长激素对摘除卵巢大鼠皮质骨的影响 |
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| 引用本文： | Huang S,Dai K,Tang T,Wang Y. 重组人生长激素对摘除卵巢大鼠皮质骨的影响[J]. 中华外科杂志, 2000, 38(1): 47-50 |
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| 作者姓名： | Huang S Dai K Tang T Wang Y |
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| 作者单位： | ：黄遂柱（上海第二医科大学附属第九人民医院骨科 200011）;黄遂柱（现在河南省人民 医院骨科,450003）;戴克戎（上海第二医科大学附属第九人民医院骨科 200011）;汤亭亭（上海第二医科大学附属第九人民医院骨科 200011） |
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| 摘 要： | 目的 探讨重组人生长激素对摘除卵巢大鼠股骨和椎体皮质骨的影响。方法 ６个月龄ＳＤ大鼠４０只,摘除卵巢后３个月开始皮下注射高、低２种剂量生长激素。注射８周后处死,取出双侧股骨和Ｌ２椎体,测定股骨中段骨密度值,观测股骨中段和椎体皮质骨厚度的改变,测定股骨生物力学强度,并与雌激素注射组比较。结果 生长激素显著增加摘除卵巢大鼠股骨中段和腰椎体皮质骨尤其是外层皮质的厚度,股骨中段骨密度值和生物力学强度出显著
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| 关 键 词： | 促生长素 卵巢摘除 骨密度 生物力学 大鼠 |
| 修稿时间： | 1999-03-04 |
Effects of recombinant human growth hormone on cortical bone of ovariectomized rats |
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| Huang S,Dai K,Tang T,Wang Y. Effects of recombinant human growth hormone on cortical bone of ovariectomized rats[J]. Chinese Journal of Surgery, 2000, 38(1): 47-50 |
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| Authors: | Huang S Dai K Tang T Wang Y |
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| Affiliation: | Department Orthopaedics of 9th Hospital, Shanghai Second Medical University, Shanghai 200011, China. |
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| Abstract: | OBJECTIVE: To study the effects of recombinant human growth hormone on cortical bone of middle femur and vertebra of variectomized rats. METHODS: Forty 6 month-old SD rats received low or high dose of growth hormone subcutaneously 3 months after ovariectomy for 8 weeks. Bone density and biomechanical strength of the femur were measured, and the thickness of cortical bone of the middle femur and L(2) vertebra was observed. The results were compared with those in estrogen group. RESULTS: Growth hormone increased the thickness of cortical bone and biomechanical strength and bone density. Estrogen therapy showed no effects on bone density and biomechanical strength of cortical bone. CONCLUSION: Recombinant human growth hormone can prevent bone loss from cortical bone of ovariectomized rat. |
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| Keywords: | Somatotropin Ovary Bone density Biomechanics |
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