骨髓增生异常综合征患者T淋巴细胞亚群的变化

骨髓增生异常综合征(MDS)的发病机制主要是造血干细胞或恶性克隆细胞获得生长优势而异常增殖,正常造血克隆受到抑制或过度凋亡,最终导致了外周血细胞减少,进而向白血病转化。细胞免疫紊乱在MDS的发病中尤为重要,正确深入地了解MDS的免疫调节机制对其治疗有重要的指导意义,本文旨在针对MDS患者的T淋巴细胞亚群数量、比例及免疫功能失调等现象进行综述。

Changes of T lymphocyte subsets in myelodysplastic syndrome patients

The pathogenesis model of myelodysplastic syndrome （MDS） is hematopoietic stem/progenitor cells or malignant clone cells growth advantage and excessive proliferation and normal hematopoiesis cloning is restrained or excessive apoptosis, leading to decreased peripheral blood cells and to leukemic transformation. Cellular immune disorder is particularly important in the pathogenesis of MDS. The correctly and deeply understanding of the MDS immune regulation mechanism has important guiding significance for its treatment. In this paper, the T lymphocyte subsets of MDS patients quantity, scale, immune dysfunction and other phenomena were summarized.