| 醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察 |
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| 引用本文： | 胡蕾,刘松青,郭薇,代青,刘蕴佳. 醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察[J]. 第三军医大学学报, 2009, 31(8) |
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| 作者姓名： | 胡蕾 刘松青 郭薇 代青 刘蕴佳 |
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| 作者单位： | 1. 第三军医大学,西南医院药学部,重庆,4000382
2. 第三军医大学,学员旅12队,重庆,400038 |
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| 摘 要： | 目的 制备醋酸曲安奈德(triameinolone-aeetonide-acetate,TAA)-聚乳酸(polylactic acid,PLA)植入剂(Im-plant),考察醋酸曲安奈德植入剂的体外释药特性.方法 采用熔融-挤出法制备TAA-PLA植入剂,高效液相色谱法测定TAA含量,绘制体外释放曲线.结果 制得的植入剂为直径0.8 mm,长约8 mm,质量约8 mg的白色柱状物,其巾TAA的载药鼍为30%,体外释放速率平稳且缓慢,第30天时TAA的累积释放率为75.84%,药物体外释放符合Higuchi方程Q=0.137×(t-0.752)1/2.结论 所制备的TAA-PLA植入剂对药物TAA有明显的缓释效果,且在体内可生物降解,毒副作用小,有望成为TAA的眼部新型给药制剂.
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| 关 键 词： | 聚乳酸 醋酸曲安奈德 眼色素层炎 巩膜植入剂 |
Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate |
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| HU Lei,LIU Song-qing,GUO Wei,Dai Qing,LIU Yun-jia. Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(8) |
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| Authors: | HU Lei LIU Song-qing GUO Wei Dai Qing LIU Yun-jia |
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| Affiliation: | HU Lei1,LIU Song-qing1,GUO Wei1,Dai Qing1,LIU Yun-jia2(1Department of Pharmacy,Southwest Hospital,212th Student Team,Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To prepare a biodegradable sckeral implant containing triamcinolone-acetonide-acetate(TAA) and polylactic acid(PLA) and investigate its release in vitro.Methods The TAA-PLA implant was prepared by melt-extrude technique.The drug release of TAA in vitro was determined by high performance liquid chromatography(HPLC).Results The implant was white pillar with 8 mm in length,8 mg in weight,and 0.8 mm in diameter.The drug loading was 30%.The drug was released at a steady and slow rate.Its accumulation r... |
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| Keywords: | polylactic acid triamcinolone acetonide acetate uveitis scleral implant |
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