豫北地区孕妇传染病与优生关系的研究

本文报告了豫北地区孕妇弓形虫病、风疹、巨细胞病毒、及布鲁氏菌病四种传染病的感染状态及其所致出生及出生后异常情况，四种传染病感染率分别为:３．４２％、０．７３％、１．１２％、０．９３％，不同年龄、孕次及孕期的感染率无明显差异，弓形虫、巨细胞病毒感染以２、３季度较高，布鲁氏菌病感染则有明显的职业性。在２８４例阳性孕妇中有４例为交叉感染。阳性孕妇临床症状发生率分别为１１．２８％、１３．０４％、１０．１４％、８．３３％。且主要表现为上感、发热等。新生儿脐血抗体测定显示孕晚期及中期感染的孕妇其新生儿中大部分保留有相关抗体，而孕早期感染者大多已消失。对２４９例阳性孕妇所生子女随访，共查出２１例异常，结果显示四种传染病所致出生及生后异常的特异危险性在１．８％－１２．７％之间。研究还显示孕早期感染较中、晚期更易导致出生异常。

A Study on the Relationship between infectious diseases of Pregnant

The situation of pregnant women infected with toxoplasmosis(Toxo),rubella(Ru),cy-tomegalovirus(CMV)and brucellosis(Br),and the abonormal conditions on birth and after birth caused by such diseases was reported.The infection rate of above 4 diseases were:3.4%,0.73%,1.12%,0.93% respectively There was no much differnce of infection rates among pregnant age,gestational time and period.Toxo and CMV were always infected higher in the second and third quarters.Br showed obvious professional features.Four cases were cross infections in 284 psitive cases. Clinical symptoms of positive cases of gravida were 11.28%,13.04%,10.14%,8.3%3%,which were mainly fever,upper resiratory tract infection and etc. Antibody test of neonatal ambilicus blood showed that most neonates born by pregnant women infected with diseases during middle and late peri-od mostly had no such associated antibodies.By follow-up survey to children born by 249 pregnants with positive reacton,21 cases were unnormal and the specific danger rate caused by such diseases be-fore birth and after birth between 1.8%-12.7%,The study also showed that it was easier to get un-normal for those infected during eatrly gestational period than those infected during middle and late pe-riod.