| IGRP与1型糖尿病的关系 |
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| 引用本文： | 吴祥梅,杨涛,周智广. IGRP与1型糖尿病的关系[J]. 国际内分泌代谢杂志, 2010, 30(Z1). DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.015 |
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| 作者姓名： | 吴祥梅 杨涛 周智广 |
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| 作者单位： | 1. 南京医科大学第一附属医院内分泌科,210029
2. 中南大学湘雅二医院代谢内分泌研究所,长沙,410011 |
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| 摘 要： | 1型糖尿病是由T细胞介导的自身免疫性疾病.许多研究表明,抗原特异性的CD4~+和CD8~+T细胞在1型糖尿病的发病过程中起重要作用.胰岛细胞特异性葡萄糖-6-磷酸酶催化亚基相关蛋白(IGRP)作为1型糖尿病的主要自身抗原之一,是葡萄糖-6-磷酸酶蛋白家族中的一员,在人和非肥胖糖尿病鼠胰腺中均有表达.它在胰岛β细胞的代谢过程中起重要作用,但是确切机制仍不清楚.IGRP的研究将有助于探索1型糖尿病诊断和治疗的新方法.
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| 关 键 词： | 1型糖尿病 自身免疫 自身抗原 |
Relationship between IGRP and type 1 diabetes |
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| WU Xiang-mei,YANG Tao,ZHOU Zhi-gnang. Relationship between IGRP and type 1 diabetes[J]. International JOurnal of Endocrinology and Metabolism, 2010, 30(Z1). DOI: 10.3760/cma.j.issn.1673-4157.2010.s1.015 |
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| Authors: | WU Xiang-mei YANG Tao ZHOU Zhi-gnang |
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| Abstract: | Type 1 diabetes is a T cell-mediated autoimmune disease. Many studies have suggested that both CD4~+ and CD8~+ T cells are involved in the pathogenesis of type 1 diabetes. Islet-specific glucose-6-phosphatase catalytic subunit related peptide (IGRP) ,which is recognized as a major autoantigen for autoim-mune type 1 diabetes, is a member of the glucose-6-phosphatsse family. IGRP is expressed in the pancreas of both human and NOD mice and is thought to have a role in islet β cell metabolism. However,its exact func-tion has not yet been defined. The research of IGRP will help to explore new methods of the diagnosis and treatment of type 1 diabetes. |
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| Keywords: | IGRP |
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