速度向量成像技术评价阿霉素致兔早期左心室收缩功能损害的研究

目的探讨速度向量成像（VVI）技术在评价阿霉素致兔早期左心室收缩功能损害中的应用价值。方法把新西兰纯种白兔41只随机分成4组：A组9只，作为对照组，注射生理盐水2ml／kg，每周1次，共8周；B组10只，注射阿霉素2ms／kg，以生理盐水稀释成1ms／ml耳缘静脉注射，每周1次，共2周；c组10只，给予相同剂量阿霉素4周；D组12只，给予相同剂量阿毒素8周。每组于停药后2周对兔心脏行常规超声心动图及左心室各节段纵向运动速度、应变、应变率检测。所有实验动物在完成超声检查后即刻处死，取出心脏，行心肌病理学检查。结果各组同一节段纵向心肌运动参数比较显示，与A组相比，B组应变测值差异无统计学意义，c组部分节段减低（P〈0．05），D组所有节段均减低（P〈0．05或P〈0．01）；心肌运动速度、应变率、左心室射血分数及左心室缩短率仅D组较A组减低（P〈0．05）。病理结果显示从B组到D组心肌损害逐渐加重。结论VVI可无创、有效地评价阿霉素致兔早期左心室收缩功能的变化。

The assessment of left ventricular systolic function in rabbits with early adriamycin-induced myocardial damage by velocity vector imaging

Objective To evaluate the experimental value of velocity vector imaging(VVI) in early assessment of left ventricular systolic function in rabbits with adriamycin-induced myocardial damage.Methods A total of 41 rabbits were classified into four groups: A group(control group): 9 rabbits were injected with 2 ml/kg of NS once per week for 8 weeks;B group: 10 rabbits were administrated with 2 mg/kg of adrimycin and diluted with NS into 1 mg/ml once per week for two weeks;C group: 10 rabbits were injected with th...