长期带涤纶环双腔导管配合尿激酶肝素混合液在血液透析中的临床应用

目的分析并评价长期带涤纶环双腔导管配合尿激酶肝素混合液应用于血液透析中的临床效果。方法将我院血透中心2009年3月至2011年6月经颈内静脉长期留置导管的50例实施血液透析患者随机分成2组,每组25例。对照组给予肝素液,观察组给予尿激酶肝素混合液,两组患者均连续应用6个月后观察临床疗效。结果观察组留置导管时间明显长于对照组(P<0.05),其血流量以及尿素清除指数明显高于对照组(P<0.05),其堵管率明显低于对照组(P<0.05),两组比较差异具有统计学意义。结论采用尿激酶肝素混合液进行血液透析长期带涤纶环双腔导管封管能够显著改善导管功能,增强透析效果,值得临床推广应用。

Clinical application of long-term use of dacron ring double lumen catheter with urokinase heparin mixture in hemodialysis

Objective To analyze and evaluate the long-term clinical effect of polyester ring double-lumen catheter with urokinase heparin mixture used in hemodialysis.Methods 50 cases of hemodialysis patients from March 2009 to June 2011 were randomly divided into two groups,25 cases in each group.The control group was given heparin,and the observation group was treated with urokinase-heparin mixture,the clinical effect of continuous application for six months of the two groups was observed.Results The indwelling catheter time of observation group was significantly longer than that of control group(P<0.05),and its blood flow and urea clearance rate was significantly higher(P<0.05),the plugging was significantly lower than that of control group(P<0.05).Conclusion The urokinase heparin mixture hemodialysis and long-term sealed tube of polyester ring double lumen catheter can significantly improve catheter function,enhance the effects of dialysis,and it is worthy of extensive promotion and application.