七氟醚吸入诱导在心脏手术病人的应用及其对呼吸循环功能的影响

目的研究七氟醚或七氟醚-N

Sevoflurane Inhalation Induction in Cardiac Patients and Its Effects on Respiration and Circulation

Objective: To study the inhalation induction with sevoflurane or sevofluraneN2O in cardiac valve disease patients and its effects on respiration and circulation. Methods: 34 patients scheduled for cardiac valve procedure were divided into two groups. Group1(n=16) was induced with sevoflurane and group2(n=18) with sevofluraneN2O as the N2O end tidal concentration reaching 50%. The side stream spirometry and SwanGanz catheter technique were used to monitor the respiratory and circulatory function. Results:Patients lost their consciousness in group1 when the ETSevf reached 23% (approximately11MAC) and when the ETN2O reached 50%, ETSevf16% (about 13MAC) in group2. The times for induction were 3 to 4 and 5 to 6 minutes respectively. The courses of induction were smooth in both groups. There were no changes in VT,MV,RR,ETCO2 and V10in group1 after induction, but VT and MV decreased significantly without an increase in RR in group2. The VT and MV between two groups were significantly different (P<001). The hemodynamic parameters of MAP,CI,LVWI,LVSWI,RVWIand RVSWI decreased significantly (P<005) in the two groups, and SI and RVSWI also decreased in group1 (P<005) during induction. Conclusion: Sevoflurane inhaled anesthesia in patients with cardiac valve disease is smooth during the induction and has a little depression on respiration and circulation.