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A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis
Authors:Mahdi Bakhshaee  Ali Taghipour  Hamideh Naghedi‐Baghdar  Masoumeh Kaboli Farshchi  Seyed Saeed Hoseini  Mohammad Reza Mehri
Affiliation:1. Department of Ear, Nose and Throat, Mashhad university of medical sciences, Mashhad, Iran;2. Department of Biostatistics and Health Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Student Research Committee, Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Student Research Committee, Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, IranCorrection added on 19 December 2017, after first online publication on 12 November 2017: The affiliation of the two authors Mohammad Reza Mehri and Majid Anushiravani has been changed.
Abstract:Chronic rhinosinusitis (CRS) is a common disease with evidence to show that its incidence and prevalence are increasing. Medicinal plants are commonly used to treat CRS. This systematic review aimed to assess the effectiveness and safety of herbal preparations for treatment of the patients with CRS. Cochran, Embase, ISI, PubMed, and Scopus databases were searched until August 1, 2016. Only randomized controlled trials were included. Four randomized controlled trials were included in this systematic review. Various medicinal plants were studied in each article. Inclusion and exclusion criteria, and outcome measures varied among different articles. The results of this trials showed that this special medicinal plants may be effective in the treatment of CRS. No serious reactions were reported during the administration of herbal remedies in the 4 studies. However, trials with a well‐designed approach are needed to study the actual safety and efficacy of herbs in the treatment of CRS.
Keywords:chronic rhinosinusitis  clinical trial  herbal medicine
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