| 手术干预糖尿病大鼠的实验研究 |
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| 引用本文： | 郭俊秀,武华,高彦斌. 手术干预糖尿病大鼠的实验研究[J]. 中国医疗前沿, 2008, 3(22): 28-29 |
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| 作者姓名： | 郭俊秀 武华 高彦斌 |
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| 作者单位： | 山西医科大学,山西,太原,030001 |
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| 摘 要： | 目的探讨Roux-en-Y胃转流术(GBP)对2型非肥胖型糖尿病鼠的降糖作用及Roux-en-Y胃转流术(GBP)对正常鼠血糖有无影响。方法雄性Wister大鼠随机分为四组,空白组(1组)、手术组(2组)、造模组(3组)、造模+手术组(4组),每组10只,测定术前,术后48小时,一周,八周的空腹血糖值,胰岛素值的变化。结果4组手术后一周空腹血糖值由(17.50±0.82)mmol/L下降到(11.08±0.60)mmol/L(P值﹤0.01)。空腹胰岛素值由(28.95±3.99)mIU/L升高到(33.83±5.61)mIU/L(P﹤0.05)至实验结束血糖无反弹。2组手术前后血糖值无明显变化。结论GBP能显著降低STZ诱导的糖尿病大鼠的血糖值,对正常鼠血糖无影响。
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| 关 键 词： | Roux-en-Y胃转流术(GBP) 糖尿病 大鼠 |
The Experimental Research on Surgical intervention in diabetic rats |
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| GUOJUNXIU,WUHUA,GAOYANBIN. The Experimental Research on Surgical intervention in diabetic rats[J]. China Healthcare Innovation, 2008, 3(22): 28-29 |
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| Authors: | GUOJUNXIU WUHUA GAOYANBIN |
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| Affiliation: | GUOJUNXIU WUHUA GAOYANBIN (Shanxi medical university; General surgery department; Taiyuan; Shanxi 030001; China); |
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| Abstract: | Objective To observe the hypoglycemic effects of gastric bypass(GBP)in streptozotocin(STZ)-induced diabetic rats and gastric bypass(GBP)for any impact on blood sugar normal mice.Methods Forty male Wister rats were randomly allocated into four groups:Blank group (Group 1),Operation group(Group 2),Model Group(Group 3),Model and operation group(Group 4).Fasting Plasma glucose concentration and insulin were measured before operation and 48 hours,1 week,8weeks,after operation in all rats.Results The four group p... |
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| Keywords: | gastric bypass（GBP） diabetes rat |
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