鼻咽癌放疗对口腔和鼻腔pH值影响的分析

 目的分析鼻咽癌放射治疗对患者口腔唾液和鼻腔分泌物pH值的影响。方法用试纸检测法检测正常对照组、鼻咽癌患者研究组和放疗后组口腔唾液和鼻腔分泌物的pH值，每组30例；其中鼻咽癌患者研究组的检测包括放疗前、放疗1、3、5周和放疗结束时5个时段；对检测的结果进行统计学比较分析，并对一些相关问题进行讨论。结果研究组放疗前、放疗1、3、5周和放疗结束患者口腔唾液（咀嚼1 min）的pH分别为6.98±0.94、6.13±0.91、5.50±0.90、5.52±0.94、5.55±1.12，放疗后组为6.11±0.64。研究组放疗前与放疗过程中的各时段及放疗后组的pH比较，差异具有统计学意义（P均=0.000）。研究组放疗前、放疗1、3、5周和放疗结束患者鼻腔分泌物的pH分别为7.14±0.26、7.13±0.26、7.20±0.31、7.33±0.27、7.28±0.34，放疗后组为7.30±0.31，研究组放疗前与放疗5周和放疗后组相比较，差异均具有统计学意义（P=0.016，P=0.014），其余组间比较差异无统计学意义（P均>0.05）。结论放疗过程中口腔唾液pH值呈现下降的趋势，从放疗的第1周末开始，唾液的pH值就明显下降，第3周就基本达到谷底，放疗后难以恢复。而放疗过程中鼻腔pH值则呈缓慢的上升状态，但变化程度相对较小。放射治疗使口腔唾液和鼻腔分泌物pH值的反向变化以及影响有待进一步研究。

Analysis of impacts of radiotherapy on pH values of oral and nasal cavity in nasopharyngeal patients

 ObjectiveTo study the impacts of radiotherapy on pH values of saliva and nasal secretion in nasopharyngeal carcinoma (NPC) patients.MethodsTest paper test was applied to detect the pH values of saliva and nasal secretion in normal subjects, NPC patients during radiotherapy and those after radiotherapy, 30 cases in each group. The time points of detection for the radiotherapy group included pre radiotherapy, one week, three weeks, five weeks and the termination of radiotherapy. The obtained data were analyzed statistically and some related issues were discussed.ResultsThe salivary PH values of the NPC group in pre radiotherapy, 1 week, 3 weeks, 5 weeks, and the termination of radiotherapy were 6.98±0.94, 6.13±0.91, 5.50±0.90, 5.52±0.94, and 5.55±1.12 respectively. And that of the postradiotherapy group was 6.11±0.64. Their differences were all statistically significant (all P=0.000). Their corresponding pH values of the nasal secretion were 7.14±0.26, 7.13±0.26, 7.20±0.31, 7.33±0.27, 7.28±0.34 and 7.30±0.31. The nasal secretion pH value before radiotherapy was lower than that at the 5th week during radiotherapy and that of the postradiotherapy group, and their differences were statistically significant (both P<0.05) while other differences were all in significant (all P>0.05).ConclusionsDuring radiotherapy of NPC patients, the salivary PH shows an irreversible downward trend starting at the first week and touching bottom at the third week. On the contrary, the nasal secretion pH value demonstrates a slow ascent with relatively minor change. The reverse changes and the effect of the salivary PH and the nasal cavity PH during radiotherapy of NPC need to be further studied.