聚乙二醇电解质散不同剂量对 便秘者肠道准备的影响

目的 比较不同剂量聚乙二醇电解质散（PEG）对便秘患者肠道准备影响。方法 对55 例结肠镜检 查患者，将其分为A、B 两组。其中，A 组26 例，B 组29 例。A 组检查当天口服2 L PEG 溶液；B 组分次口服 4 L PEG 溶液。肠道清洁度采用波士顿量表评分（BBPS），记录是否检出大肠息肉、不良反应及对药物口感评 价。结果 两组BBPS 评分总分、左半结肠、中段结肠及右半结肠评分比较，差异有统计学意义（P <0.05）；两 组息肉检出率、不良反应及对药物口感的评价比较，差异无统计学意义（P >0.05）。分层分析：B 组男性与女性 BBPS 评分总分和右半结肠评分比较，差异有统计学意义（P <0.05）；A 组男性与女性BBPS 评分比较，差异无统 计学意义（P >0.05）。两组有无腹部手术史BBPS 评分比较，差异无统计学意义（P >0.05）。结论 对于慢性便秘 患者，分次口服4 L PEG 溶液方案较口服2 L 方案肠道清洁效果好。

Effect of Polyethylene glycol electrolyte powder on bowel preparation for constipation patients

Objective To compare the efficacy of different doses of Polyethylene glycol electrolyte powder (PEG) on the quality of bowel preparation in patients with constipation. Methods Totally 55 cases were involved in this study and divided into two groups: group A in which patients received 2 L whole-dose PEG (n = 26) and group Bin which patients received 4 L spilt-dose PEG (n = 29). All patients received colonoscopy afterwards. Boston bowel preparation scale (BBPS) was used to assess the intestinal cleanliness. The adverse reactions and evaluation of drug taste were recorded. Results Statistically significant difference in BBPS total score, and score in the left colon, the middle colon and the right colon were witnessed in two groups (P < 0.05). No obvious difference was observed between two groups in terms of colonic polyp detection rate, adverse reaction and evaluation of drug taste (P > 0.05). Hierarchical analysis revealed that the BBPS score in the total and the right colon were higher in female patients of group B than that of male patients (P < 0.05). There was no statistically significant difference in BBPS score between the male and the female in group A (P > 0.05). History of abdominal surgery exerted no significant impact on BBPS score in both groups (P > 0.05). Conclusions 4 L spilt-dose PEG is a better option for chronic constipation patients.