恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展

外泌体是纳米(30~150 nm)膜结合囊泡,内部包含多种生物活性物质,如脂质、蛋白质、mRNA以及非编码RNA等,在正常和病理条件下几乎所有细胞都可以分泌。研究发现肿瘤细胞可通过分泌外泌体将核酸、蛋白质等生物活性分子传递给受体细胞,改变受体细胞的表型或功能,进一步改变肿瘤微环境而影响肿瘤的进展。本文根据研究进展对肿瘤细胞外泌体在改变巨噬细胞表型方面所发挥的作用进行简要的介绍。

Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages

Exosomes are nanometer(30~150 nm)membrane-bound vesicles,which contain a variety of bioactive substances,such as lipids,proteins,mRNA,and non-coding RNA,which can be secreted by almost all cells under normal and pathological conditions.Many studies have found that tumor cells can deliver bioactive molecules such as nucleic acid and proteins to recipient cells by secreting exosomes,changing the phenotype or function of recipient cells,and further changing the tumor microenvironment to affect tumor progression.Based on the research progress,this article briefly introduces the role of tumor exosomes in changing the phenotype of macrophage.