某院住院癫痫患儿抗菌药物的使用情况分析

摘要] 目的:调查抗菌药物在住院癫痫患儿中的使用情况,评价用药的合理性。 方法:在电子病历系统检索2015 年 6-12 月诊断为癫痫的249 例患儿,回顾性分析抗菌药物的使用情况,包括抗菌药物使用指征、品种选择、用法用量及用药疗程等。 结果: 249 份癫痫患儿病历中有 178 例使用了抗菌药物,抗菌药物使用率为 71.49% 。 所用抗菌药物主要是广谱青霉素类和头孢菌素 类药物,其中排名前 3 位的分别是五水头孢唑林(31.46% )、头孢他啶(20.79% )和磺苄西林(16.85% )。 抗菌药物在癫痫患儿 中不合理用药率为 30.34% ,以联合用药不适宜和无正当理由超说明书用药为主,分别为 10.67% 和 8.99% 。 结论:抗菌药物在 癫痫住院患儿中存在不合理应用,应加强抗菌药物的临床应用管理,保证儿童用药安全。

Analysis of Antibiotics in Hospitalized Children with Epilepsy

Abstract] Objective: To investigate the use of antibiotics in hospitalized children with epilepsy, and evaluate the rationality of medication. Methods: A total of 249 cases of epilepsy were retrieved in the electronic record system from June to December 2015 to retrospectively analyze the use of antibiotics, including indications, varieties, usage and dosage, and duration of antibiotics, etc. Results : Among the 249 children, 178 children used antibiotics, the rate of antibiotics was 71.49%. Broad-spectrum penicillin and cephalosporin were the main varieties of antibiotics consumed, the top three of which were cefazolin sodium pentahydrate (31.46% ), ceftazidime (20.79% ) and sulbenicillin (16.85% ). The irrational antibiotics use rate in epilepsy children was 30.34% , the main of unreasonable use were inappropriate drug combination (10.67% ) and off-labeled drug use (8.99% ). Conclusion: Irrational use of antibiotics exists in children with epilepsy. We should strengthen the management of clinical application of antibiotics to ensure the safety of drug use in children.