原发性胃淋巴瘤中APC 蛋白的表达及其意义

目的 研究分析原发性胃淋巴瘤（PGL）组织中腺瘤性结肠息肉病（APC）蛋白的表达，以及与临床病理特征的关系，探讨APC 蛋白在PGL 发生、发展中的作用及意义。方法 选取2006 年6 月-2011 年12 月中南大学湘雅医院、湖南省邵阳市中医医院PGL 术后患者的临床资料和手术病理标本。采用免疫组织化学法检测45 例PGL 和30 例胃正常黏膜组织中APC 蛋白的表达。结果 PGL 和胃正常黏膜组织中APC 蛋白阳性表达率分别为37.78% 和90.0%，差异有统计学意义（P <0.05）。PGL 组织中有无淋巴结转移和不同临床分期的APC 蛋白阳性表达率比较，差异有统计学意义（P <0.05）。不同年龄、性别及大体形态的APC 蛋白阳性表达率比较，差异无统计学意义（P >0.05）。结论 APC 蛋白在PGL 中低表达，是PGL 发生的一个重要原因，提示APC 蛋白可作为PGL 发生的一个重要检测指标。

Expression and significance of APC protein in primary gastriclymphoma

Objective To study the expression of adenomatous polyposis coli (APC) protein in primary gastriclymphoma (PGL) tissue, and explore its relationships with clinicopathological features, as well as the role of APCprotein in the development and progress of PGL. Methods The clinical and pathological data of 45 patients withPGL admitted in Xiangya Hospital and Shaoyang Chinese Medicine Hospital between June 2006 and December 2011 were collected. The expression of APC protein in 45 cases of PGL and 30 samples of normal gastric mucosatissue was studied with immunohistochemical staining (SP). Results The positive expression rate of APC proteinwas 37.78% in the PGL tissues and 90.00% in the normal gastric mucosa tissue, there was a significant difference(P < 0.05). There was no significant difference in the positive expression rate of APC protein among the patientswith different genders, age or gross tumor morphology (P > 0.05). The positive expression rate of APC proteinwas correlated with clinical stage and lymph node metastasis (P < 0.05). Conclusions The APC protein is lowlyexpressed in PGL, and it plays an important role in the tumorigenesis of PGL, and may be an important potentialpredictor of tumorigenesis in PGL.