| 盆腔器官脱垂与COL3A1基因多态性的Meta分析 |
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| 引用本文： | 樊冬梅,杨夏楠,齐朋伟,晋熙梦,张蕾,赵丹丹.盆腔器官脱垂与COL3A1基因多态性的Meta分析[J].西部医学,2018,30(3):413-417. |
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| 作者姓名： | 樊冬梅 杨夏楠 齐朋伟 晋熙梦 张蕾 赵丹丹 |
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| 作者单位： | 河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300,河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300,河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300,河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300,河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300,河南科技大学临床医学院·河南科技大学第一附属医院妇产科，河南 洛阳 471300 |
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| 摘 要： | 背景 一些学者研究表明，胶原蛋白类型3α1（COL3A1）rs180025与盆腔器官脱垂的发生有一定关联性，而另外一些学者则持相反的意见。目的 评估COL3A1基因多态性是否为盆腔器官脱垂发生的危险因素。方法 从多个数据库包括Medline、Embase、万方、中国知网等检索相关文章，语言和国家不限，但所选文章均为病例对照研究。提取数据并采取RevMan5.2软件进行Meta分析。结果 共纳入1274名参与者(701例病例和573例对照)。等位基因A vs G: OR=0.98, 95%CI 0.67，1.43, P=0.92;纯合子模型AA vs GG， OR=1.51, 95%CI 0.47，4.82, P=0.48;杂合子模型GA vs GG: OR=0.89,95%CI 0.69，0.14,P=0.37;显性模型GA+AA vs GG: OR=092, 95%CI 0.63，1.33, P=0.65; 隐性模型AA vs GA+AA: OR=1.64, 95%CI 0.54，4.95, P=0.38。结论 COL3A1基因的多态性与盆腔器官脱垂的发生无明显相关性,但盆腔器官脱垂的发生可能和种族有关。
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| 关 键 词： | 盆腔器官脱垂 基因多态性 Meta分析 系统评价 |
The association between COL3A1 and pelvic organ prolapse: Systemic and Meta-Analysis |
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| FAN Dongmei,YANG Xianan,QI Pengwei,JIN Ximeng,ZHANG Lei and ZHAO Dandan.The association between COL3A1 and pelvic organ prolapse: Systemic and Meta-Analysis[J].Medical Journal of West China,2018,30(3):413-417. |
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| Authors: | FAN Dongmei YANG Xianan QI Pengwei JIN Ximeng ZHANG Lei and ZHAO Dandan |
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| Institution: | Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China,Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China,Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China,Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China,Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China and Department of Gynaecology and Obsterics, The First Affiliated Hospital of Henan University of Science and Technology, College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China |
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| Abstract: | |
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| Keywords: | Pelvic organ prolapse Genetic epidemiology Meta analysis Systematic evaluation |
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