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| 微透析技术在靶组织局部药物浓度检测中的应用 | |
| 引用本文： | 李静,潘国凤,周英,王海南.微透析技术在靶组织局部药物浓度检测中的应用[J].中国临床药理学杂志,2012,28(5):396-398. |
| 作者姓名： | 李静 潘国凤 周英 王海南 |
| 作者单位： | 1. 贵州大学生命科学学院药物化学,贵阳,550025 2. 首都医科大学附属北京世纪坛医院中医科,北京,100038 3. 国家食品药品监督管理局药品注册司,北京,100053 |
| 基金项目： | 国家自然科学基金资助项目(81001564) |
| 摘 要： | 微透析技术是一项越来越被广泛使用的在体研究技术,其遵循透析原理,以探针为基础取样,可连续检测局部组织细胞外液的药物浓度,能满足常规的药代动力学/药效学(PK-PD)研究。本文就其在靶组织局部药物浓度检测中的应用作一简要介绍。 |
| 关 键 词： | 微透析技术 靶组织 局部药物浓度 |
Application of microdialysis technique in monitoring local drug concentration in tissue-targeted |
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| LI Jing , PAN Guo-feng , ZHOU Ying , WANG Hai-nan.Application of microdialysis technique in monitoring local drug concentration in tissue-targeted[J].The Chinese Journal of Clinical Pharmacology,2012,28(5):396-398. | |
| Authors: | LI Jing PAN Guo-feng ZHOU Ying WANG Hai-nan |
| Institution: | 1.Pharmaceutical Chemistry,College of Life Sciences,Guizhou University,Guiyang 550025,China;2.Department of Traditional Chinese Medicine,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;3.Division of Drug Registration,State Food and Drug Administration,Beijing 100053,China) |
| Abstract: | Microdialysis,based on the dialysis principle,is a new probe-based sampling technique in vivo which can continuous monitoring drug concentration of extracellular fluid in local tissues during several hours and days.It satisfies regulatory requirements for pharmacokinetic-pharmacodynamic(PK-PD) studies,and could provide scientific basis for the development of new drugs and clinical rational drug use.This review presents the monitoring local drug concentration in tissue-targeted by microdialysis technique. |
| Keywords: | microdialysis tissue-targeted local drug concentration |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |