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| 头孢丙烯分散片在中国健康人体的药代动力学 | |
| 引用本文： | 丁细桃,李军伟,邱相君,刘涛,胡国新. 头孢丙烯分散片在中国健康人体的药代动力学[J]. 中国临床药理学杂志, 2012, 28(2): 107-109 |
| 作者姓名： | 丁细桃 李军伟 邱相君 刘涛 胡国新 |
| 作者单位： | 1. 温州医学院机能实验教学中心,浙江温州,325035 2. 温州医学院药学院,浙江温州,325035 3. 河南科技大学医学院,河南洛阳,471003 |
| 摘 要： | 目的研究头孢丙烯分散片在中国健康人体的药代动力学。方法 10名中国健康受试者,男女各半,单剂量口服头孢丙烯分散片500 mg。用高效液相色谱法同时测定血浆中顺式和反式头孢丙烯的浓度;用DAS 2.0药代动力学程序计算药代动力学参数。结果头孢丙烯的主要药代动力学参数:Cmax为(9.62±1.29)mg.L-1,Tmax为(1.30±0.35)h,t1/2(ke)为(1.32±0.15)h,V为(34.40±5.48)L,CL为(18.16±2.96)L.h-1,AUC0-10为(27.68±4.45)mg.h.L-1,AUC0-∞为(28.22±4.70)mg.h.L-1。结论头孢丙烯在人体内符合一级吸收的一室模型。 |
| 关 键 词： | 头孢丙烯 分散片 药代动力学 高效液相色谱法 |
Pharmacokinetics of cefprozil dispersible tablets in Chinese healthy volunteers |
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| DING Xi-tao , LI Jun-wei , QIU Xiang-jun , LIU Tao , HU Guo-xin. Pharmacokinetics of cefprozil dispersible tablets in Chinese healthy volunteers[J]. The Chinese Journal of Clinical Pharmacology, 2012, 28(2): 107-109 | |
| Authors: | DING Xi-tao LI Jun-wei QIU Xiang-jun LIU Tao HU Guo-xin |
| Affiliation: | 1b (1.a.Teaching Center of Medical Functional Experiment;b.School of Pharmacy,Wenzhou Medical College,Wenzhou 325035,Zhejiang Province,China;2.Medical College of Henan University of Science and Technology,Luoyang 471003,Henan Province,China) |
| Abstract: | Objective To study the pharmacokinetics of cefprozil dispersible tablets in healthy volunteers.Methods Ten healthy volunteers(five males and five females) received 500 mg cefprozil dispersible tablets at a single oral dose.The concentrations of cis-cefprozil and trans-cefprozil in plasma were determined simultaneously by HPLC.The pharmacokinetic parameters were calculated by DAS program.Results After a single dose of 500 mg cefprozil dispersible tablets,the pharmacokinetic parameters for cefprozil were as follows: Cmax was(9.62±1.29) mg·L-1,Tmax was(1.30±0.35)h,t1/2(ke) was(1.32±0.15) h,V was(34.40±5.48) L,CL was(18.16±2.96) L·h-1,AUC0-10was(27.68±4.45) mg·h·L-1,AUC0-∞ was(28.22±4.70) mg·h·L-1.Conclusion Cefprozil was fitted to a one-compartment model with first absorption. |
| Keywords: | cefprozil dispersible tablets pharmacokinetics high performance liquid chromatography |
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