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| 代谢组学技术在神经精神性疾病中的应用研究进展 | |
| 引用本文： | 江沛,蔡骅琳,李焕德,陈琳瑶. 代谢组学技术在神经精神性疾病中的应用研究进展[J]. 中国临床药理学杂志, 2012, 28(7): 550-553 |
| 作者姓名： | 江沛 蔡骅琳 李焕德 陈琳瑶 |
| 作者单位： | 1. 中南大学 湘雅二医院 临床药学研究室,长沙 410011;中南大学 药学院,长沙 410013 2. 中南大学 湘雅二医院 临床药学研究室,长沙,410011 3. 中南大学 药学院,长沙,410013 |
| 摘 要： | 神经精神性疾病的发病过程,一般与氧化应激、神经递质和脂肪酸代谢紊乱及线粒体功能异常有关。代谢组学技术则能通过分析比较不同病理生理状态下体内小分子代谢产物,全面监测多条与疾病相关的代谢通路,进而寻找有价值的生物标志物,揭示其病理过程。本文主要对代谢组学技术在精神分裂症、抑郁症、帕金森等神经精神性疾病中的应用进行了综述。 |
| 关 键 词： | 代谢组学 神经精神性疾病 生物标志物 |
Progress of metabolomics in the neuropsychiatric diseases |
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| JIANG pei , CAI Hua-lin , LI Huan-de , CHEN Lin-yao. Progress of metabolomics in the neuropsychiatric diseases[J]. The Chinese Journal of Clinical Pharmacology, 2012, 28(7): 550-553 | |
| Authors: | JIANG pei CAI Hua-lin LI Huan-de CHEN Lin-yao |
| Affiliation: | 1.Clinical Pharmacy Research Institute,The Xiangya Second Hospital,Central South University,Changsha 41001,China;2.Scholl of Pharmaceutical Sciences,Central South University,Changsha 410013,China) |
| Abstract: | Neuropsychiatric diseases are linked to disturbances in metabolic pathways related to neurotransmitters,fatty acids,oxidative stress and mitochondrial function.Though cataloguing of the small molecular metabolites that existed in any particular organism and maping in greater detail perturbations in many biochemical pathways,metabolomics enable us to find the disease-specific biomarkers and pathological mechanism.In this review,recent advances in metabolomics are briefly introduced.We also highlight recent findings from metabolomic studies in CNS diseases such as schizophrenia,depression,Parkinson’s disease,et al. |
| Keywords: | metabolomics neuropsychiatric diseases biomarkers |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |