急性脑梗死患者血清白细胞介素-18和基质金属蛋白酶-9水平及其临床意义

目的探讨急性脑梗死患者血清白细胞介素-18(IL-18)和基质金属蛋白酶-9(MMP-9)水平的变化及其临床意义。方法 53例急性脑梗死患者,根据脑梗死体积和临床神经功能缺损程度评分分组。采用酶联免疫吸附法(ELISA)检测血清IL-18和MMP-9水平并与正常对照组比较。应用SPSS 13.0版统计软件进行分析。结果急性脑梗死患者血清IL-18和MMP-9水平明显高于正常对照组(P<0.01),大梗死组患者血清IL-18和MMP-9水平高于小梗死组(P<0.05),患者血清IL-18和MMP-9水平与脑梗死体积呈正相关(P<0.05);轻型组、中型组、重型组患者血清IL-18和MMP-9水平依次升高,各组之间差异有统计学意义(P<0.05),患者血清IL-18和MMP-9水平与临床神经功能缺损程度评分呈正相关(P<0.05)。结论急性脑梗死患者血清IL-18和MMP-9水平升高;血清IL–18和MMP-9水平与脑梗死体积及临床神经功能缺损程度相关,检测其水平有助于判断急性脑梗死患者的病情及预后。

Clinical significance of serum IL-18 and MMP-9 levels in patients with acute cerebral infarction

Objective To investigate the serum interleukin-18(IL-18)and matrix metalloproteinase-9(MMP-9)levels in patients with acute cerebral infarction(ACI)and the clinical significance.Methods 53 patients with ACI were selected.According to the volume of infarction and the standard of clinical neurologic impairment degree score,they were divided into different groups.In all subjects,the serum IL-18 and MMP-9 concentrations were detected by enzyme-linked immunosorbent assay(ELISA).Comparison and analysis were performed by using a SPSS 13.0 soft.Results The serum IL-18 and MMP-9 levels in the patients with ACI were significantly higher than those in the healthy subjects(P<0.01).The serum levels of IL-18 and MMP-9 increased with the volumes of infarction,the differences between the groups were significant(P<0.05).The serum levels of IL-18 and MMP-9 were correlated with the volumes of infarction(P<0.05).The serum levels of IL-18 and MMP-9 increased with the clinical neurologic impairment degree scores,the differences among the groups were significant(all P<0.05).The serum levels of IL-18 and MMP-9 were correlated with the clinical impairment neurologic degree scores(P<0.05).Conclusions The serum levels of IL-18 and MMP-9 are significantly elevated in the patients with ACI.The serum levels of IL-18 and MMP-9 are correlated with the volumes of infarction and the clinical neurologic impairment degree scores.Detecting the serum levels of IL-18 and MMP-9 would be helpful for estimating the severity and prognosis of ACI.