本院鲍曼不动杆菌近5年耐药率的变化趋势

目的分析本院近5年鲍曼不动杆菌耐药率变化情况。方法选择2007～2011年本院住院患者分离的鲍曼不动杆菌604株,并分析8种抗菌药物使用情况。结果头孢哌酮/舒巴坦5年来均保持高度敏感性,耐药率<10%。对亚胺培南也有较高的敏感性,耐药率从2008年的6.6%,上升到2011年的15.3%。对头孢曲松敏感性较低,耐药率从2007年的65.2%上升到2011年的84.9%。对左氧氟沙星的敏感性也较低,从2007年的37.9%上升到2011年的53.1%。结论鲍曼不动杆菌耐药率逐年增高,医院应合理使用抗菌药物,以减少多重耐药菌的产生。

Trend of change of antimicrobial resistance against Acinetobacter baumannii in our hospital from the year 2007 to 2011

Objective To analysis the trend of change of antimicrobial resistance against Acinetobacter baumannii in our hospital from the year 2007 to 2011.MethodsA retrospective survey methods was used.The isolates of 604 strain of Acinetobacter baumannii was collected in our hospital from January 2007 to December 2011.The 8 kinds of antimicrobial agents against Acinetobacter baumannii was analyzed.ResultsCefoperazone/sulbactam to maintain the high sensitivity of the average annual resistance rate(<10%) in recent 5 years.Imipenem has more sensitivity to Acinetobacter baumannii,the resistance rate were from 6.6% in 2008 up to 15.3% in 2011.To ceftriaxone and levofloxacin resistance rates were from 65.2% in 2007 and up to 84.9% in 2011 and to levofloxacin resistance rate were from 37.9% in 2007 up to 53.1% in 2011.ConclusionThe resistance rate to Acinetobacter baumannii is rising year by year respectively.Hospital shoud be rational drug use in order to reduce the generation of malti-drug resistant was occured.