| 细胞色素P450(CYP450)4A11与CYP4F2基因多态性与心血管疾病的相关性 |
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| 引用本文： | 刘俊花,石磊,赵树进. 细胞色素P450(CYP450)4A11与CYP4F2基因多态性与心血管疾病的相关性[J]. 中国临床药理学杂志, 2012, 28(5): 392-395 |
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| 作者姓名： | 刘俊花 石磊 赵树进 |
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| 作者单位： | 广州军区广州总医院药学部,广州,510010 |
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| 基金项目： | 广东省科技计划基金资助项目(2009B080701105) |
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| 摘 要： | 细胞色素P450(CYP)ω-羟化酶主要包括CYP4A11和CYP4F2,代谢花生四烯酸(AA)生成20-羟化二十碳四烯酸(20-HETE),20-HETE具有收缩血管和促进尿钠排泄等作用。CYP4A11和4F2基因具有高度多态性,这种多态性导致酶活性降低,并可能引起某些心血管疾病。
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| 关 键 词： | 细胞色素P4504A11与4F2 基因多态性 心血管疾病 |
Relationship between cytochrome P450( CYP450)4A11 and CYP4F2 polymorphism and cardiovascular diseases |
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| LIU Jun-hua , SHI Lei , ZHAO Shu-jin. Relationship between cytochrome P450( CYP450)4A11 and CYP4F2 polymorphism and cardiovascular diseases[J]. The Chinese Journal of Clinical Pharmacology, 2012, 28(5): 392-395 |
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| Authors: | LIU Jun-hua SHI Lei ZHAO Shu-jin |
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| Affiliation: | (The Department of Pharmacy,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China) |
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| Abstract: | Cytochrome P450(CYP450)ω-hydroxylases including CYP4A11 and CYP4F2 metabolize arachidonic acid(AA) to 20-hydroxyeicosatetraenoic acid(20-HETE) which has both vasoconstricting and natriuretic effects.Genetic polymorphisms causing lower activity of these enzymes are generally associated with risk of cardiovascular diseases. |
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| Keywords: | cytochrome P450 4A11 and 4F2 single nucleotide polymorphisms cardiovascular diseases |
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