| 载脂蛋白E基因多态性对调血脂药临床疗效研究进展 |
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| 引用本文： | 罗余萍,熊玉卿. 载脂蛋白E基因多态性对调血脂药临床疗效研究进展[J]. 中国临床药理学杂志, 2012, 28(6): 465-468 |
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| 作者姓名： | 罗余萍 熊玉卿 |
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| 作者单位： | 南昌大学 医学院 临床药理研究所,南昌,330006 |
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| 摘 要： | 载脂蛋白E是维持人类正常脂质代谢的重要物质,是一种遗传多态性蛋白,存在于多种脂蛋白中。不同基因表型调节着体内载脂蛋白E的代谢能力及其与受体的结合能力。本文对载脂蛋白E基因多态性与调血脂药临床疗效的相关性进行综述。
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| 关 键 词： | 载脂蛋白E 遗传多态性 高脂血症 调血脂药 |
Progress in efficacy of apolipoprotein E polymorphisms on antihyperlipidemic |
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| LUO Yu-ping , XIONG Yu-qing. Progress in efficacy of apolipoprotein E polymorphisms on antihyperlipidemic[J]. The Chinese Journal of Clinical Pharmacology, 2012, 28(6): 465-468 |
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| Authors: | LUO Yu-ping XIONG Yu-qing |
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| Affiliation: | (Institute of Clinical Pharmacology,Medical College of Nanchang University,Nanchang 330006,China) |
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| Abstract: | Apolipoprotein E plays an important role in maintaining cholesterol homeostasis.It exists in several classes of plasma lipoproteins.Apolipoprotein E was confirmed to be a protein with genetic polymorphism.Different phenotype mediates the capability of metabolism and binding ability to acceptors in vivo.This paper aimed to give a review about the relationship between apolipoprotein E polymorphisms and the clinical efficacy of antihyperlipidemic based on previous studies,so as to provide scientific grounds for these drugs′ reasonable usage in clinic. |
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| Keywords: | apolipoprotein E genetic polymorphism hyperlipidemia antihyperlipidemic |
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