| 氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍的稳定性 |
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| 引用本文： | 张敬阳,郑芳,朱雪.氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍的稳定性[J].郧阳医学院学报,2011,30(1):68-70. |
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| 作者姓名： | 张敬阳 郑芳 朱雪 |
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| 作者单位： | 张敬阳,ZHANG Jing-yang(湖北医药学院附属东风医院,口腔医院,湖北,十堰,442008);郑芳,朱雪,ZHENG Fang,ZHU Xue(湖北医药学院附属东风医院,药剂部,湖北,十堰,442008) |
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| 摘 要： | 目的:考察室温(25±1)℃]下,氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍的稳定性,为临床合理用药提供科学依据。方法:采用反相高效液相色谱法,色谱柱为Agilent HC C18,乙腈-0.05 mol.L-1磷酸二氢钾溶液(18︰82)为流动相,测定配伍液中氟康唑与甲磺酸帕珠沙星0～6 h内的含量变化,并观察配伍液的外观及pH值。结果:氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液6 h内配伍液外观、pH及含量均无明显变化。结论:在室温(25±1)℃]下,氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍后6 h内可使用。
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| 关 键 词： | 氟康唑 甲磺酸帕珠沙星 高效液相色谱法 配伍 稳定性 |
Stability and Compatibility of Fluconazole Sodium Chloride Injection Mixed with Pazufloxacin Mesilate Injection |
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| ZHANG Jing-yang,ZHENG Fang,ZHU Xue.Stability and Compatibility of Fluconazole Sodium Chloride Injection Mixed with Pazufloxacin Mesilate Injection[J].Journal of Yunyang Medical College,2011,30(1):68-70. |
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| Authors: | ZHANG Jing-yang ZHENG Fang ZHU Xue |
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| Abstract: | Objective To study the stability of fluconazole sodium chloride injection and pazufloxacin mesilate injection at room temperature(25±1) ℃,in order to supply evidence of clinical rational administration.Methods The content changes of fluconazole and pazufloxacin mesilate were determined by RP-HPLC,in which the Agilent HC C18 column was used,the mobile phase was acetonitrile-0.05 mol·L-1 potassium dihydrogen phosphate solution(18︰82)and the changes of appearance,pH values were observed within 6 hours.Results There were no significant changes in the contents,appearance and pH values of the compatible solution at room temperature(25±1)℃ for 6 h.Conclusion The mixture of fluconazole and sodium chloride injection with pazufloxacin mesilate injection could be safely used within 6 h at room temperature(25±1) ℃]. |
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| Keywords: | Fluconazole Pazufloxacin mesilate HPLC Compatibility Stability |
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