原发性肾病综合征患者血脂及载脂蛋白的变化

目的 :研究原发性肾病综合征 （NS）患者血清总胆固醇 （TC）、甘油三酯 （TG）、高密度脂蛋白胆固醇 （HDL- c）、低密度脂蛋白胆固醇 （L DL- c）、载脂蛋白 apo A1 ,apo B1 0 0 含量和 apo A1 /apo B1 0 0 及其临床意义。方法 :检测 5 0例原发性 NS患者与 5 0例健康人 （对照组 ）的血脂及脂蛋白 ,并进行比较。结果 :原发性 NS患者血清 TC,TG,L DL- c,apo B1 0 0 较对照组显著升高 （P<0 .0 1） ,而 apo A1 /apo B1 0 0 较对照组显著下降 （P<0 .0 5 ）。结论 :NS患者存在着明显的脂代谢紊乱。

Changes of serum lipoprotein and apoprotein in patients suffering from primary nephritic syndrome

AIM:To observe the changes of serum total cholesteryl(TC),triglyceride(TG),high density lipoprotein(HDL-c),low density lopoprotein(LDL-c),apoprotein A 1(apoA 1),apoproteinB 100(apoB 100) and apoA 1/apoB 100 in patients with primary nephrotic syndrome(NS) and to explore their clinical significance. METHODS:Serum lopoprotein and apoprotein of 50 NS patients and 50 healthy cases (as the control) were measured and compared. RESULTS:The serum content of TC,TG,LDL-c,apo100 were significantly high compared with those of the control group(P<0.01). Whereas the apoA 1/apoB 100 was significantly low(P<0.05). CONCLUSION:Fat metabolism disorder occurs in NS patients.