Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats |
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Authors: | Noriaki Koshikawa Katsunori Tomiyama Kiyomi Omiya Masafumi Kobayashi |
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Affiliation: | Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan. |
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Abstract: | Striatal levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid and homovanillic acid in rats were not altered for at least 6 h after a ketamine injection (100 mg/kg). Striatal DA turnover which was measured by giving alpha-methyl-p-tyrosine after ketamine was unchanged. Even the dose regimen of ketamine which anaesthetized animals for approximately 3.5 h (100 mg/kg + 5 maintenance injections of 50 mg/kg at 30 min intervals) produced no alteration in DA turnover for at least 9 h. These results suggest that ketamine anaesthesia will not adversely affect studies investigating central DAergic mechanisms in rats. |
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Keywords: | Ketamine anesthesia Striatum Dopamine turnover 3,4-Dihydroxyphenylacetic acid Homovanillic acid Rat |
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