Minocycline inhibits neuroinflammation and enhances vascular endothelial growth factor expression in a cerebral ischemia/reperfusion rat model |
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| Authors: | Zhiyou Cai Yong Yan Changyin Yu Jun Zhang |
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| Institution: | Zhiyou Cai1,Yong Yan1,Changyin Yu2,Jun Zhang2 1Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing Key Laboratory of Neurology,Chongqing 400016,China 2Department of Neurology,the Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou Province,China |
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| Abstract: | BACKGROUND: Brain ischemia involves secondary inflammation, which significantly contributes to the outcome of ischemic insults. Vascular endothelial growth factor (VEGF) may play an important role in the vascular response to cerebral ischemia, because ischemia stimulates VEGF expression in the brain, and VEGF promotes formation of new cerebral blood vessels. Minocycline, a tetracycline derivative, protects against cerebral ischemia and reduces inflammation, oxidative stress, and apoptosis. OBJECTIVE: To obs... |
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| Keywords: | cerebral ischemia/reperfusion inflammation minocycline vascular endothelial growth factor |
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