异丙酚对猕猴失血性休克复苏血浆前列环素和血栓素变化的影响

目的:观察异丙酚对猕猴失血性休克并复苏血浆前列环素(PGI2)和血栓素(TXA2)变化的影响。方法:12只失血性休克并复苏模型的猕猴被随机分为两组。对照组除用同等容量生理盐水代替异丙酚外,其余与异丙酚组相同;异丙酚组则在放血前用计算机靶控输注技术使猴血浆异丙酚浓度达到8mg/L并维持此水平。分别于放血前、失血性休克2h时和全部自体血及液体复苏2h时抽取血标本,用放免法测定血浆PGI2和TXA2含量。结果:在复苏2h时,对照组TXA2水平显著升高(P<0.05),而异丙酚组TXA2水平恢复至放血前水平,异丙酚组TXA2水平明显低于对照组(P=0.0001),PGI2/TXA2明显高于对照组(P=0.0001)。结论:在失血性休克并复苏猕猴,异丙酚能降低休克复苏所致的血浆TXA2水平升高的幅度,改善休克复苏所致的PGI2与TXA2平衡失调,改善休克的预后。

Effect of propofol on prostacyclin and thromboxane during hemorrhagic shock and resuscitation in monkeys

Objective:To investigate the effect of propofol on the plasma concentrations of prostacyclin(PGI_(2)) and thromboxane A_(2)(TXA_(2)). Methods:Twelve monkeys with hemorrhagic shock were devided randomly into two groups.The monkeys in propofol group received propofol at plasma concentration 8mg/L by target control infusion,while monkeys in control group received normal saline in the same.Venous blood were collected to determine plasma prostacyclin (PGI_(2)) and thromboxaneA_(2)(TXA_(2))concentrations by radio-immunoassay before bleeding, 2 hours after hemorrhagic shock and 2 hours after resuscitation. (Results:Compared) with control group's,the TXA_(2 )level of propofol group was significantly lower at 2 hours after resuscitation((P=0.0001)), and the ratio of PGI_(2)/TXA_(2) of propofol group was higher(P=0.0001). Conclusion:These findings indicate that propofol can decrease the plasma concentration of TXA_(2) in hemorrhagic shock and resuscitation monkeys,which may be beneficial to control the development of hemorrhagic shock.