原发性高血压赖诺普利治疗前后血清胰岛素样生长因子-I的变化

目的观察原发性高血压(EH)患者服用赖诺普利治疗前后血清胰岛素样生长因子-I(IGF-I)的变化,探讨IGF-I在EH的发生发展过程中所起的可能作用。方法47例EH患者均行超声心动图检查,用放免法测定赖诺普利治疗前、治疗后半年及23例正常对照者血清IGF-I水平。结果EH患者血清IGF-I水平明显高于对照组分别为(22.23±10.06)ng/ml对(15.91±7.59)ng/ml,P<0.01。I~Ⅲ级间比较也有显著性差异(F=3.53,P<0.05),Ⅲ级(28.61±13.10)ng/ml高于Ⅱ级(22.64±9.94)ng/ml,Ⅱ级高于I级(18.09±6.11)ng/ml。EH伴左心室肥厚(LVH)者高于无LVH者(25.95±11.20)ng/ml对(18.68±7.43)ng/ml,P<0.05。IGF-I与左心室重量指数中度相关(r=0.54)。赖诺普利治疗6个月后,血清IGF-I水平由(22.23±10.06)ng/ml降至(16.82±7.93)ng/ml,P<0.05。结论EHLVH患者IGF-I水平升高,赖诺普利治疗后IGF-I水平下降,IGF-I可能参与EHLVH的形成。

Changes of serum insulin-like growth factor-I levels in patients with essential hypertension before and after lisinopril treatment

Objective To observe the change of serum insulin-like growth factor-I (IGF-I) levels in patients with essential hypertension before and after lisinopril treatment,and to investigate the possible effects of IGF-I in the occurrence and development of essential hypertension. Methods Forty-seven patients with essential hypertension were studied using echocardiography. Serum IGF-I levels were measured by radioimmunoassay in 47 patients with essential hypertension before and after six months of treatment with lisinopril as well as in 23 normotensive controls. Results Baseline levels of IGF-I were higher in essential hypertension patients than in normotensive controls (22.23±10.06)ng/ml vs (15.91±7.59)ng/ml,P<0.01.There was a great difference between I～Ⅲ degree patients (F=3.53, P<0.05). IGF-I levels were higher in Ⅲ degree patients (28.61±13.10)ng/ml than those in Ⅱ degree patients (22.64±9.94)ng/ml, and in Ⅱ degree patients were higher than those in I degree patients (18.09±6.11)ng/ml. Mean IGF-I level was higher in essential hypertension with left ventricular hypertrophy (LVH) than in those without LVH (25.95±11.20)ng/ml vs (18.68 ±7.43)ng/ml,P<0.05. There was a positive correlation between the serum IGF-I and left ventricular mass index (r=0.54). After six months treatment of lisinopril , serum IGF-I levels fell to (16.82±7.93)ng/ml(P<0.05). Conclusion Serum IGF-I levels increased in essential hypertension with LVH and decreased after treatment of lisinopril. IGF-I may be involved in the essential hypertension associated LVH.