| 大鼠背根节神经元异位自发放电与钙依赖性钾通道的关系 |
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| 引用本文： | 邢俊玲 胡三觉. 大鼠背根节神经元异位自发放电与钙依赖性钾通道的关系[J]. 医学争鸣, 1998, 19(6): 614-617 |
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| 作者姓名： | 邢俊玲 胡三觉 |
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| 作者单位： | 第四军医大学基础部神经科学研究所!西安，710033，第四军医大学基础部神经科学研究所!西安，710033 |
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| 基金项目： | 国家自然科学基金!39670247 |
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| 摘 要： | 探讨神经元异位自发电的产生机制。方法分离背根单纤维，引导来自损伤背根节神经元的异位自发放电，观察Ｃａ＾２＋和Ｋ＾＋离子浓度变化及有关通道阻断剂其的影响。
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| 关 键 词： | 背根神经节 异位自发放电 钙依赖性钾道 神经元 |
Relationship between calcium dependent potassium channel and ectopic spontaneous discharge of dosal root ganglion neurons in the rat |
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| XING Jun-Ling,HU San-Jue. Relationship between calcium dependent potassium channel and ectopic spontaneous discharge of dosal root ganglion neurons in the rat[J]. Negative, 1998, 19(6): 614-617 |
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| Authors: | XING Jun-Ling HU San-Jue |
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| Abstract: | Aim: To elucidate the producing mechanism ofectopic spontaneous discharge (ESD) in neurons. Methods:Single dorsal root fibre was separated, the ESD conductedfrom injured dorsal root ganglion (DRG) neurons wasrecorded and the effects of the concentration of K+ and Ca2+and channel blockers were observed. Results: During[Ca2+]. had been enchanced or caffeine used, the number ofESD were inhibited while using Ni2+ or EGTA it werefacilitated. The increment of [K+]. and TEA could bothfacilitate the ESD. Apamin, a specific antagonist of calciumdependent potossium channel K (Ca), had markedly increasingeffect on ESD. Conclusion: The change of [Ca2+] can effectthe number of ESD from injured DRG neurons, whichmaybe act through the activation or inactivation of K(Ca). |
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| Keywords: | dorsal root ganglion ectopic spontaneous discharge calcium dependent potassium channel |
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