番茄红素对急性肺损伤大鼠肺泡巨噬细胞影响

目的观察番茄红素对急性肺损伤大鼠肺泡巨噬细胞吞噬功能的影响。方法以0．5，1．0，3．0mg／（kg·bw）的番茄红素连续给雄性Wistar大鼠灌胃30d，用脂多糖制造大鼠急性肺损伤模型，分别在1，4，6h后支气管肺泡灌洗，检测肺泡巨噬细胞吞噬功能、细胞计数以及肺相对重等指标。结果在各剂量番茄红素作用下，肺泡巨噬细胞吞噬功能明显增强，与模型组相比，注射脂多糖1h后，喂饲番茄红素组吞噬功能增强，增强率分别为11．2％，27．9％，38．1％；4h后，增强率分别为5．9％，4．4％，17．0％；6h后，增强率分别为16．6％，15．2％和21．9％。番茄红素3个剂量组之间呈剂量-反应关系（P〈0．05）。结论番茄红素在0．5，1．0，3．0mg／（kg·bw）剂量下能增强肺泡巨噬细胞的吞噬功能。

Effect of Iycopene on function of pulmonary alveolar macrophages of rat's acute lung injury

Objective To study the effect of lycopene on the function of pulmonary alveolar macrophages(PAMs)of rat's acute lung injury(ALI).Methods Male rats were gavaged continuously by lycopene with 0.5,1.0,3.0?mg/kg for 30 days;Lipopolysaccharide was used to make the model of ALI rats.After 1?hour,4 and 6?hours,bronchoalveolar lavage was done,and the function of PAMs,the amount of PAMs and the lung relative weight were determined.Results Lycopene could increase the phagocytic function of PAMs significantly.Compared with the model group,the phagocytic function of PAMs was increased significantly in lycopene groups,with increasing rates of 11.2%,27.9%,38.1% after injection of LPS for 1 hour,with increasing rates of 5.9%,4.4%,17.0% after injection of LPS for 4 hours,and with increasing rates of 16.6%,15.2%,21.9% after injection of LPS for 6 hours,respectivelely compared with the model group.The phagocytic function of PAMs was increased obviously by three different dose of lycopene,showing a dose-response relationship(P<0.05).Conclusion Lycopene,at the dose of 0.5,1.0 and 3.0?mg/kg,could reinforce the phagocytic function of PAMs.