银丹心脑通软胶囊调血脂作用的实验研究

目的观察银丹心脑通软胶囊对饮食性高脂血症大鼠血脂改变的影响。方法 Wistar大鼠随机分组,建立饮食性高脂血症大鼠模型成功后,灌胃给予银丹心脑通软胶囊治疗4wk,取外周血测定血脂和载脂蛋白。结果与正常组比较,模型组大鼠总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和载脂蛋白-A均显著升高,而体重下降;与模型组比较,银丹心脑通软胶囊高剂量治疗组及阳性药血脂康胶囊治疗组大鼠总胆固醇、低密度脂蛋白显著降低,但仍高于正常组,体重没有明显改变。结论银丹心脑通软胶囊降低对组织器官损害较大的高脂血症大鼠血中总胆固醇和低密度脂蛋白效果显著,具有抗高脂血症的作用,其作用机制有待进一步探讨。

Experimental study on improving hyperlipidemia of Ying Dan Xin Nao Tong Capsulae Molles

Objective To study the effects of Ying Dan Xin Nao Tong capsulae molles（YDCM） on improving blood fat in hyperlipidemia rat.Methods Wistar rats were randomly divided into 5 groups.Hyperlipidemia model rats were administered with high fat diet for 12 weeks.And some of hyperlipidemi rats were treated with YDCM.The weight and total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C）,high density lipoprotein（HDL-C） and apoprotein were detected.Results Compared with normal group,TC,TG,LDL-C and lipoprotein A（Apo-A） were increased in hyperlipema model rats,but body weight were decreased.TC and LDL-C were lower in YDCM 0.5g/kg/d group than model group,but higher than normal group.The body weight was no chang in YDCM group.YDCM and XZK have no affect Apo-A and lipoprotein B（Apo-B） in hyperlipema rats.Conclusions YDCM could improve hyperlipemia in rats.It principally decreased TC and LDL-C that were most hazardous in tissue and organs.The mechanism of YDCM on the effect will be futher researched.