肺嗜酸细胞腺癌的临床病理观察

目的 探讨肺嗜酸细胞腺癌的临床病理特征。方法 运用光镜、电镜及免疫组化方法观察1例肺嗜酸细胞腺癌并复习相关文献。结果 组织病理学特点：肿瘤无包膜，浸润性生长，明显坏死，瘤组织由含有嗜酸性颗粒胞质的细胞构成，细胞和核显著多形性。免疫组化：CK（＋）、EMA、Syn、CgA和S-100（-）。电镜：瘤细胞胞质内充满大量线粒体，无神经内分泌颗粒。结论 肺嗜酸细胞癌是一种极其少见的恶性肿瘤，形态学上应与肺的嗜酸细胞性类癌、嗜酸细胞腺瘤、转移性嗜酸细胞腺癌等相鉴别，免疫组化染色和电镜观察在该肿瘤的诊断和鉴别诊断中具有重要作用。

Oncocytic carcinoma of lung: a clinicopathological observation

Objective To investigate the clinicopathological features of oncocytic carcinoma of the lung.Methods A case of oncocytic carcinoma of the lung was studied by light microscopy, electron microscopy,immunohistochemical stains and review of the literature. Results Histopathologically, the tumor showed no capsule, invasive growth and significant necrosis. The tumor was mostly composed of cells with eosinophilic granules in the cytoplasm, obvious cell and nuclear polymorphism. Immunohistochemically, the tumor cells were positive for CK, whereas EMA, Syn, CgA, and S-100 protein were negative.Uhrastructurally, the oncocytic cells showed large numbers of mitochondria but no neurosecretory granules. Conclusion Pulmonary oncocytic carcinoma is an extremely rare malignant tumor. Morphologically, it is necessary to differentiate from oncocytic carcinoid tumor, oncocytoma, and metastatic oncocytic carcinoma. Immunohistochemical stains and electronic microscopy play important roles in the diagnosis and differential diagnosis.