胃癌患者手术前后外周血中IL-2/IL-2R系统的动态变化

目的 探讨胃癌病人外周血中ＩＬ－２，ＳＩＬ－２Ｒ水平及ＣＤ２５表达三者手术前后的动态变化和相互关系。方法 分别采用ＥＬＩＳＡ法、免疫我法对５０例胃癌患者手术前后外周血中ＩＬ－２、ＳＩＬ－２Ｒ水平及ＣＤ２５表达进行检测。结果 胃癌患者手术前后外周血中ＩＬ－２水平及ＣＤ２５表达的均低于对照组，而ＳＩＬ－２Ｒ水平均高于对照组；切除肿瘤后ＩＬ－２水平及ＣＤ２５表达较术前升高，而ＳＩＬ－２Ｒ水平较术前下降；

The Dynamic Study on IL-2/IL-2 R system in Peripheral Venous Blood Before and after Surgery Inpatients with Gastrit Carcinoma

Objective To determine the dynamic changes of the levels of IL 2,sIL 2R and the expression of CD 25 ,the relationship among them,in patients with gastric carcinoma.Method The levels of IL 2,sIL 2R and the expression of CD 25 in the peripheral blood in 50 patients with gastric carcinoma were assayed by ELISA,immunofluoresence methods,respectively.Result The level of IL 2 and the expression of CD 25 in peripheral blood in patients with gastric carcinoma before and after surgery were lower than those of the reference group,but the level of sIL 2R was higher than that of the reference group.The level of IL 2 and the expression of CD 25 after surgery were higher than those before surgery,but the level of sIL 2R after surgery was lower than that before surgery.The level of IL 2 and the expression of CD 25 decreased,the level of sIL 2R increased again when the metastases or recurrences of tumor occurred in 6 patients after surgery.There was significantly negative correlation between the level of sIL 2R and that of IL 2 before surgery.Conclusion The abnormality of IL 2/IL 2R system closely related to the immunologic hypofunction existed in the patients with gastric carcinoma before surgery and the metastases or recurrences of tumor after surgery.