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CIRCADIAN DRINKING PATTERN OF SARDINIAN ALCOHOL-PREFERRING RATS |
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| Authors: | AGABIO, ROBERTA CORTIS, GIAMPIERO FADDA, FABIO GESSA, GIAN LUIGI LOBINA, CARLA REALI, ROBERTA COLOMBO, GIANCARLO |
| Affiliation: | ‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari Via Porcell 4, 1-09124 Cagliari 1‘Bernard B. Brodie’ Department of Neuroscience, Institutes of Forensic Medicine, University of Cagliari Via Porcell 4, 1-09124 Cagliari 2‘Bernard B. Brodie’ Department of Neuroscience, Institutes of Human Physiology, University of Cagliari Via Porcell 4, 1-09124 Cagliari 3C.N.R. Centre for Neuropharmacology Via Porcell 4, 1-09124 Cagliari, Italy |
| Abstract: | The present study was designed to assess the temporal patternof ethanol intake over a 24 h period in selectively bred, Sardinianalcohol-preferring (sP) rats Ethanol intake occurred under thetwo-bottle, free choice regimen. sP rats consumed ethanol inthree distinct peaks, rather regularly distributed over the12 h dark phase of the light-dark cycle and positively correlatedwith food intake episodes. The temporal distribution of ethanolintake and estimated blood alcohol levels are consistent withthe hypothesis that sP rats voluntarily drink ethanol for itspharmacological effects |
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