|
|||||
|
|
| 维生素B12溶液鼻粘膜吸收的研究 | |
| 引用本文： | 维生素B12溶液鼻粘膜吸收的研究[J]. 中国药科大学学报, 2002, (1): 19-22. |
| 作者姓名： | 杨建红 张钧寿 史雪燕 孙颖 |
| 作者单位： | 1. 河北省药品检验所，石家庄，050011 2. 中国药科大学药剂教研室，南京，210009 3. 石家庄康平医药研究所,石家庄,050021 4. 河北省老年病医院麻醉科，石家庄,050011 |
| 摘 要： | 目的：研究维生素B12溶液鼻粘膜吸收规律。方法：以大鼠在体鼻循环法为实验模型，考查循环液浓度不同时，维生素B12鼻粘膜吸收规律。结果：考察了0.25,0.5,1mg/ml三种浓度的维生素B12溶液鼻粘膜吸收规律，表明不同浓度的维生素B12鼻粘膜吸收速度为一常数。结论：维生素B12溶液鼻粘膜吸收机制为被动扩散，吸收符合一级动力学，吸收速度常数K为0．02441min^-1。 |
| 关 键 词： | 维生素B12 在体鼻循环法 鼻粘膜 吸收速度常数 研究 |
| 文章编号： | 1000-5048(2002)01-0017-04 |
Studies on Nasal Absorption of Vitamin B_(12) Solution |
|
| Studies on Nasal Absorption of Vitamin B_(12) Solution[J]. Journal of China Pharmaceutical University, 2002, (1): 19-22. | |
| Authors: | YANG Jian-Hong ZHANG Jun-Shou SHI Xue-Yan SUN Ying HeBei Institute for Drug Control Shijiazhuang |
| Affiliation: | YANG Jian-Hong,ZHANG Jun-Shou 1,SHI Xue-Yan 2,SUN Ying 3 HeBei Institute for Drug Control,Shijiazhuang 050011, 1Department of pharmaceutics,China Pharmaceutical University,Nanjing 210009, 2Kang Ping medicinal Institute of Shijiazhuang,Shij |
| Abstract: | AIM The purpose is to investigate the regulation of vitamin B 12 nasal absorption. METHODS Rat in situ nasal recirculation mathods as experimental model were used. The effects of perfusion concentration on nasal absorption of vitamin B 12 were studied. RESULTS We studied on nasal absorption regulation of three concentrations: 0.25,0.5,1.0 mg/ml, indicating that the absorption rate of different concentration is a constant. CONCLUSION The mechanism of vitamin B 12 nasal absorption is passive diffusion, following first-order kinetics, and the absorption rate constant is 0.02441min -1 . |
| Keywords: | Vitamin B 12 In situ nasal recirculation method Nasal mucosa Absorption rate constant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中国药科大学学报》浏览原始摘要信息 | |
| 点击此处可从《中国药科大学学报》下载全文 | |