液基细胞学应用于宫颈癌筛查的临床研究

目的:评价液基细胞学(th inprep cytology test,TCT)薄片制片对宫颈癌筛查的准确性。方法:采用TCT制片及传统宫颈细胞涂片法分别对2 246例、2 635例受检者进行宫颈癌筛查。细胞诊断采用TBS分级系统,所有意义不明的不典型鳞状上皮(ASCUS)以上病变的受检者全部在阴道镜下活检。结果:TCT薄片法和传统巴氏涂片法对低度鳞状上皮内病变(LSIL)以上病变的检出率分别为4.1%、1.56%,两者结果差异有显著性意义(P<0.01)。Th inPrep液基细胞学检出LSIL、高度鳞状上皮内病变(HSIL)、鳞状细胞癌(SCC)与阴道镜活检阳性符合率分别为81.82%、90.91%、100%。传统宫颈巴氏涂片法检出LSIL、HSIL、SCC与阴道镜活检阳性符合率分别为55.17%、55.56%、100%。两种方法比较差异有显著性意义(P<0.05)。结论:Th inPrep液基细胞学检查敏感性明显高于传统宫颈细胞涂片法,能大大提高检出率,尤其是对LSIL和HSIL的患者。

Study on Cervix Carcinoma Screening with Liquid-based Cytology Test

Objective To evaluate the efficacy of liquid-based cytology test for screening cervix carcinoma.Methods 2246 and 2635 patients were screened for cervical carcinoma with TCT and traditional cervical cells smears respectively.Cell diagnosis adopted TBS-group system,all the subjects of above-ASCUS pathological changes were examined with colposcope.Results The above-LISL pathological changes identified by TCT and traditional smears were 4.1% and 1.56 % respectively.There was significant difference between them(P<0.01).The detection rates by TCT and traditional cervical cells smears were all 100% for SCC,90.91% and 55.56% for HSIL,and 81.82%,55.17% for LSIL.There was distinct difference between them(P< 0.05).Conclusion TCT is more sensitive than traditional cervical cells smears.Liquid-based cytology can improve the detection rate of LSIL in cervical screen,especially in LISL and HSIL.