| 人口腔鳞癌细胞系对淋巴靶向葫芦素BE聚乳酸纳米微粒的敏感性研究 |
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| 引用本文： | 杨凯,王昌美,温玉明,李龙江,王晓毅,陈绍维.人口腔鳞癌细胞系对淋巴靶向葫芦素BE聚乳酸纳米微粒的敏感性研究[J].华西口腔医学杂志,2002,20(4):293-295. |
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| 作者姓名： | 杨凯 王昌美 温玉明 李龙江 王晓毅 陈绍维 |
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| 作者单位： | 400016 重庆医科大学附属第一医院口腔颌面外科 (杨 凯),四川大学华西口腔医学院(王昌美,温玉明,李龙江,王晓毅),中山大学附属第二医院口腔外科(陈绍维) |
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| 基金项目： | 卫生部科学基金 (编号 98_1_2 2 1)，重庆医科大学附
属第一医院科研启动基金 (编号 2 0 0 2 0 0 7) |
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| 摘 要： | 目的:探讨人口腔鳞癌细胞系(Tca8113和BcaCD885)对颈淋巴结靶向性葫芦素BE聚乳酸纳米微粒(CuBE- PLA-NP)的敏感性。方法:用四唑盐显色法(MTT法)检测用不同剂量的CuBE-PLA-NP和CuBE在1~8 d内8个时间点对Tca8113和BcaCD885的抗癌活性,计算出2种药物在8个时间点对2种癌细胞的抑癌率和药物的半数抑癌率浓度。结果:CuBE-PLA-NP和CuBE对Tca8113和BcaCD885均有强的杀伤作用,其杀伤效应均呈时间依赖性和剂量依赖性。结论:经改型后的淋巴靶向CuBE-PLA-NP没有降低CuBE成份的抗癌活性,同时,由于CuBE-PLA-NP具有淋巴靶向性,更有利于杀灭口腔癌颈淋巴结转移灶内的癌细胞。
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| 关 键 词： | 葫芦素BE 聚乳酸 钠米微粒 口腔癌 颈淋巴结转移 靶向化疗 四唑盐显色法 |
| 收稿时间： | 2002-08-25 |
| 修稿时间： | 2001年8月31日 |
Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines |
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| Yang Kai.Effects of Cucurbitacin BE Polylactic Acid Nanoparticles on Human Oral Squamous Carcinoma Cell Lines[J].West China Journal of Stomatology,2002,20(4):293-295. |
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| Authors: | Yang Kai |
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| Institution: | Yang Kai Department ofStomatology, the First MedicalHospital, ChongqingMedicalUniversity Wang Changmei, Wen Yuming, Li Longjiang, et al West China College ofStomatology, Sichuan University |
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| Abstract: | Objective:The aim of this study was to study cytotoxic effects of cucurbitacin BE polylactic acid nanoparticles (CuBE_PLA_NP) on human oral squamous carcinoma cell lines Tca8113 (tongue carcinoma) and BcaCD885 (buccal carcinoma).Methods:The chemosensitivity of Tca8113 and BcaCD885 to CuBE_PLA_NP and CuBE was tested using MTT assay, the inhibitory rate and 50% inhibition concentrations values (IC_50) of these two drugs against these two cancer cell lines were evaluated in 1,2,3,4,5,6,7 and 8 days with different concentrations.Results:Both CuBE_PLA_NP and CuBE showed very high anti_cancer effects on Tca8113 and BcaCD855, and the anticancer efficacy of these two drugs was dose_ and time_dependent.Conclusion:The effects of CuBE_PLA_NP on lymph nodes of metastatic cancer cells were higher than that of CuBE. |
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| Keywords: | cucurbitacinBE polylactic acid nanoparticles oral carcinoma cervical lymph node metastasis targeted chemotherapy MTT assay\ |
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