腰椎骨密度定量CT检测在肾性骨病早期诊断中的应用

目的 :研究慢性肾功能不全 (CRF)患者骨密度的变化 ,探讨腰椎QCT BMD检测在肾性骨病早期诊断中的价值。方法 :6 0例CRF患者按不同年限和临床RBD诊断分组 ,应用QCT技术分别检测其 2～ 4腰椎椎体松质骨BMD ,并与年龄、性别相匹配的正常人腰椎BMD进行比较分析。结果 :6 0例CRF患者有 5 4例 (90 .0 % )骨密度降低 (T值 <- 1.0 ) ,其中 2 2例 (36 .7% )T值 <- 2 .5 ,明显低于相应年龄性别正常对照组 ,并随CRF时间延长BMD进一步降低 ,CRF临床骨病组与非骨病组BMD无明显差异。结论 :长期CRF患者骨矿含量明显降低且与时间呈正相关 ,QCT BMD检测敏感性和准确性高 ,对肾性骨病的早期诊断具有较大的应用价值

Measurement of Lumbar bone Mineral Density with Quantitative Computed Tomography in Renal Bone Disease

Objective To research the changes of the lumbar bone mineral density(BMD) in chronic renal failure(CRF) patients, and significance of quantitative computed tomography(QCT) on lumbar BMD. Methods The lumbar BMD(L2～4) were measured with QCT in sixty CRF patients ,and a comparison was made with respect to the results of lumbar BMD between CRF patients and normal subjects. Results The BMD of CRF patients were significantly lower than those of the sex-age matched normal group,and with prolongation CRF duration,the decrease of BMD became more obvious. No statistical significance was found in BMD between bone disease group and no bone disease group. Conclusions The BMD of CRF patients obviously decrease,and there was correlation between the BMD and duration. QCT-BMD is a useful sensitive diagnostic method for renal bone disease in CRF patients.