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Paroxysmal neuronal depolarizations in the rat motor cortex in vivo: intracellular injection of the calcium agonist BAY K 8644 |
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| Authors: | J. Walden H. Pockberger E. -J. Speckmann H. Petsche |
| Affiliation: | 1. Physiologisches Institut der Universit?t, Robert-Koch-Str. 27a, D-4400, Münster, Federal Republic of Germany 2. Neurophysiologisches Institut der Universit?t, W?hringer Str. 17, A-1090, Wien, Austria |
| Abstract: | Summary Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and afterdepolarization of paroxysmal neuronal depolarizations. |
| Keywords: | Epilepsy Paroxysmal depolarization shifts Motor cortical neurons Calcium agonist BAY K 8644 Calcium |
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